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Antje Körner Group: "Childhood Obesity & Endocrinology"

Research topics

​Adipose tissue development in children

Normal adipose tissue development is critical for maintaining a healthy metabolic state. An excess accumulation of adipose tissue mass in childhood or adolescence results in obesity. This is often associated with pathological metabolic and cardiovascular alterations. In this project, we aim to identify and characterize regulators of adipose tissue development and obesity. For this, we apply a translational approach combining in vitro and in vivo studies with the analyses of adipose tissue samples of lean and obese children (Leipzig Adipose Childhood Cohort).

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Clinical and experimental pediatric endocrinology

Obesity-related adipocyte dysfunction can be manifested already during childhood. Clinically and experimentally, we are examining the consequences of childhood obesity for the endocrine function of adipose tissue and the impact on the children’s development. Furthermore, we investigate gene variants leading to monogenetic obesity.

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Development of childhood obesity and associated metabolic and cardiovascular comorbidities

Alterations of the cardiovascular system and the circadian rhythm are frequent complications seen in obese children and adults. In this context we aim to decipher the communication of adipose tissue and the cardiovascular system as well as the circadian rhythm in obese children and young adults.

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Genetic and epigenetic background of adipose tissue development and early-onset obesity in children

The aim of this project is to identify new functional candidate genes involved human adipogenesis and adipose tissue dysfunction as a cause for early-onset obesity and associated insulin resistance in children.

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Group members

A list of our current and former group members and our MD students you can find here.

Publications

​A list of our publications you can find here​​.

 

Funding

  • Deutsche Forschungsgemeinschaft (DFG) ​ 
  • Klinische Forschergruppe (KFO)152 Atherobesity; K03512/1+2 atherobesity 
  • Sonderforschungsbereich (SFB)1052 Obesity Mechanisms; C1052/C5​                                                                                                     SFB_logo.jpg   ​

News & announcements

      • 23.06.2021: Published online now: We present new evidence on growth alterations in children with obesity here. (pdf). We provide height reference values specific for children with obesity  --> FREE access via Ped(z)App, CrescNet, R-package.
      • 15.05.2021: Published online now: We present longitudinal evidence of non-alcoholic fatty liver disease as a risk factor for dysglycemia in children here (pdf).
            • 01.04.2021: Prof. Dr. Antje Körner will receive funding from the German Research Foundation for sequencing in childhood cohorts in collaboration with Prof. Dr. Eleftheria Zeggini ("Molecular resolutions of diabesity in children").
                • 10.03.2021: A milestone for research in Saxony: The “SaxoChiLD” (Saxonian Child health innovation Leipzig-Dresden) project becomes a partner of the new German Research Center for Child and Youth Health and is coordinated by Prof. Dr. Antje Körner. Please find more information here.
                • 10.11.2020: Prof. Dr. Antje Körner  has received the internationally prestigious Research Award of the European Society for Paediatric Endocrinology (ESPE) 2020 for achievements of outstanding quality in pediatric endocrinology for her work in experimental and clinical childhood obesity research. The award winners can be found here.
              • 26.09.2019: Dr. Kathrin Landgraf received the Yound Investigators Award by the scientific journal "Molecular Metabolism" for presenting the best abstract at the 7th Helmholtz Diabetes Conference held in Munich.
            • 15.05.2019​: Now there is mechanistic evidence - also for humans: breastfeeding is the best to do for the baby. As a pediatrician I am really happy to have contributed to this study by Tamás Röszer demonstrating that lipid species in the breast milk preserve energy burning beige adipocytes and can protect against obesity.
              Here you can find the full article and the abstract video:
              Original publication in J Clin Invest. 2019. https://doi.org/10.1172/JCI125646.
          • 12.02.2019: Dr. Kathrin Landgraf was honored to give a talk at this year's Keystone Symposia Conference "Obesity and Adipose Tissue Biology" in Banff, Alberta, Canada. She presented her work on the obesity susceptibility gene TMEM18 to highly renowned scientists in this field.
        • 28.01.2019: We published a Letter to our data on "Acceleration of BMI in Early Childhood and Risk of Sustained Obesity" recently appearing in New England Journal of Medicine in response to the comments from Harnois-Leblanc et al. and Ichikawa. Please find the letters here.
      • 21.01.2019: Elena Kempf received the Young Scientist Prize 2019Young Scientist Prize 2019 in the category "Obesity" awarded at the Leipzig Research Festival of the Faculty of Medicine and the Faculty of Life Sciences with her work on "Characterization of subcutaneous stromal vascular cells in order to establish new cell models for human adipogenesis".
    • 4.10.2018: Our latest data on the critical age of development of obesity in children are now published in the New England Journal of Medicine. In this large population-based longitudinal study, we show that obesity manifests early in life in children and once present has a very likelihood to persist. The most excessive weight gain occurred early - between 2 and 6 years of age - and subsequently continued at a lower but still constantly positive rate which further worsens obesity.
      Find full article including "abstract video" here.
      N Engl J Med 2018; 379:1303-1312; DOI: 10.1056/NEJMoa1803527

      Unsere Ergebnisse zum kritischen Alter der Entwicklung von Übergewicht bei Kindern sind jetzt publiziert im New England Journal of Medicine. In dieser großen, populationsbasierten, longitudinalen Studie zeigen wir, dass Übergewicht sehr zeitig im Leben bei Kindern manifestiert und wenn einmal vorhanden, eine hohe Persistenz zeigt. Die größte exzessive Gewichtszunahme passiert in jungen Jahren im Alter zwischen 2 und 6 Jahren. Auch danach erfolgt eine kontinuierliche weitere Gewichtszunahme, welche das Ausmaß der Adipositas weiter verstärkt.
  • Dr. Jo Ana Schunter will receive this year's Dr. Carl-Zeise-Award of the Medical Faculty of the University of Leipzig for one of the best theses. As a medical student she had set up, persued and published a study and showing an association of a genetic variation in the FoxD3 gene with vitiligo (an autoimmune disorder of skin depigmentation) and autoimmune thyroid dysfunction.
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  • 8.08.2018: Martha Hanschkow received the "ESPE Early Career Scientific Development Grant" by the European Society of Pediatric Endocrinology and works as a visiting scientist in the lab of Dr. Anne Bouloumie in Toulouse, where she works on the characterization of the stromavascular fraction of adipose tissue samples.

Positions available

Thesis projects / dissertations

Vacant positions

Currently there are vacant positions in the group of Prof. Körner:

 

Contact

​Prof. Dr. med. Antje Körner
Center for Pediatric Research Leipzig (CPL)
(Medizinisches Forschungszentrum, Haus C)
Liebigstraße 21
04103 Leipzig
Germany

Tel:     +49 / (0)341 - 97 26500
Fax:    +49 / (0)341 - 97 26069
E-Mail: Antje.Koerner@medizin.uni-leipzig.de

Collaborations

  • University of Leipzig, Institute for Medical Informatics, Statistics and Epidemiology (IMISE), Leipzig, Germany

     Prof. Dr. Markus Scholz

  • Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Leipzig, Germany

     Prof. Dr. Matthias Blüher

     PD Dr. Nora Klöting

     PD Dr. Dr. John Heiker

     Clinical Trial Unit

 
  • Helmholtz-Centre for Environmental Research (UFZ), Leipzig, Germany

     Prof. Dr. Ana Zenclussen    

     Prof. Dr. Martin von Bergen

     Prof. Dr. Annika Jahnke Berger

  • Helmholtz-Center for Environmental Health (HMGU), Munich, Germany 
     Institute of Experimental Genetics (IEG), Neuherberg, Germany
     Dr. Raffaele Teperino
 
     Institute of Translational Genomics (ITG), Neuherberg, Germany
     Prof. Dr. Eleftheria Zeggini
 
     Institute of Stem Cell Research (ISF), Neuherberg, Germany
     Dr. Anna Pertek
 
    
 
  • Ulm University, Ulm, Germany

     Prof. Dr. Martin Wabitsch

     Dr. Tamás Röszer

  • Hannover Medical School, Hannover, Germany

     Prof. Dr. Nico Lachmann

  • Charité-Universitätsmedizin Berlin, Berlin, Germany

      Dr. Peter Kühnen

  • University of Witten/Herdecke, Datteln, Germany

     Prof. Dr. Thomas Reinehr

  • Paracelsus Medical University, Salzburg, Austria

     Prof. Dr. Daniel Weghuber

  • Joslin Diabetes Center, Boston, MA, USA

     Dr. Yu-Hua Tseng

  • van Andel Institute, Grand Rapids, MI, USA

     Prof. Dr. Andrew Pospisilik

  • University of Cambridge, Cambridge, UK

     Prof. Dr. Sadaf Farooqi

  • INSERM, University of Toulouse, Toulouse, France

     Dr. Anne Bouloumie-Diehl

  • Erasmus University Rotterdam, Rotterdam, Netherlands

     Dr. Janine Felix

  • University of Melbourne, Melbourne, Australia

     Prof. Dr. Matt Sabin 

  • Ben-Gurion University of the Negev, Be`er Sheva, Israel

     Prof. Dr. Assaf Rudich

     Prof. Dr. Iris Shai

 

   


 

 

Clinical studies and biobanks

Overview of all our clinical studies and available biobanks

NORMAL CONTROL PEDIATRIC POPULATIONS

Leipzig school children project:
= representative normal populations
n~3000 total; n~1200 for consented DNA analysis

LIFE Child Health:
= longitudinal childhood population including detailed anthropometric and metabolic phenotyping
n>3500 total (ongoing)
More information


OBESE PEDIATRIC POPULATIONS

Leipzig Obesity Childhood Cohort:
incl. detailed phenotyping and oGTT's n>2200 (incl. follow-ups n>500)

Leipzig Atherobesity Childhood Cohort:
obese children n=100 and lean children n=70
incl. detailed metabolic and cardiovascular phenotyping and MRI scans as well as follow-up data

LIFE Child Obesity:
= longitudinal childhood population incl. detailed metabolic phenotyping
n>340 participants in total (n>680 visits, incl. follow-ups)
More information


SPECIAL POPULATIONS

Intervention in obese children:

= inpatients, 6 week exercise intervention
n=62 incl. detailed phenotyping

Leipzig Circadian Rhythm Cohort:

= young healthy lean and obese adults incl. frequent serum sampling over 30 h
n=59 incl. detailed metabolic phenotyping

Adipose tissue pediatric biobank:

= adipose tissue samples from lean and obese children incl. consented DNA analysis
n=467 total currently (incl. 395 samples), ongoing study


PEDIATRIC POPULATIONS FOR GENOTYPING

n~1000 incl. MetaboChip data:
cohorts contributed to MAGIC and EGG consortia, collaborations and publications
- Metabolic traits (Scott, Nature genet Epub) collaboration
- intrauterine growth (Hokoshi, Nature Epub) collaboration
- available for own analyses

n>2000 incl. targeted (candidate) genetic analyses and GWAS replication:
- FTO (Dina, Nat genet 2007) collaboration
- GWAS (Meyre, Nat genet 2009; Scherag, PLoS genet 2010) collaboration
- TCF7L2 (Körner, JCEM 2007)
- Metabolic traits (Windholz, PLoS One 2011)
- GPR120 (Ichimura, Nature Epub) collaboration

n~3000 incl. ExomeChip data (currently done in collaboration with
Wellcome Trust, UK):
- available for own analyses (in collaboration with WTTC)


SUMMARY

n~5000 data sets from according cohorts (ongoing)

n~2750 lean, n~1750 obese (ongoing)

n~2800 incl. consented DNA analysis (ongoing)

n>1800 incl. oGTT's (ongoing)


 

SETMELANOTIDE PHASE 2 TREATMENT TRIAL IN PATIENTS WITH RARE GENETIC DISORDERS OF OBESITY

Besides the common multifactorial and polygenetic causes of obesity, there are also rare cases of single gene mutations interfering with the hypothalamic control of satiety and thus leading to obesity. Those patients are mostly severely affected and present with extreme early-onset obesity and hyperphagia. Setmelanotide, a new drug targeting the MC4-receptor dependent hypothalamic satiety control has shown promising results during the first years of clinical experience. The department of pediatrics at the university hospital in Leipzig is now able to provide treatment with Setmelanotide through an international multicenter clinical trial (NCT03013543) for some of those rare genetic disorders. For more details, please contact us.

Contact details

Prof. Dr. med. Antje Körner

Principal investigator   

Phone.: +49 341 9726500   

E-Mail: antje.koerner@medizin.uni-leipzig.de  

 

​Dr. med. Robert Stein

​Deputy PI

​Phone.: +49 341 9720296

E-Mail: robert.stein@medizin.uni-leipzig.de

 

Childhood Obesity Follow-up Study

 Aim of the study

Obesity is a life-long burden that often starts already during childhood, although obesity-associated comorbidities such as diabetes, fatty liver disease and atherosclerosis may manifest later in life. This study aims to explore the transition of children with obesity into adulthood from a comprehensive biological, (epi) genetic, environmental and sociopsychological perspective. We will emphasize on risk factors as well as protective factors during childhood that enable the prediction of disease progression during adulthood. We are collaborating with the Helmholtz Institute for Metabolic, Obesity and Vascular Research (HIMAG), as well as the LIFE Child Study.

Who may participate?

People who meet the following requirements:

  • Adults at the age of 18 and above that have been treated for obesity during childhood at the university hospital Leipzig

     
    What happens during the study?

    You will undergo the following examinations:
  • Structured reporting of medical history and completion of questionnaires targeting lifestyle, environment and well-being
  • determination of body measurements (weight, height, BMI etc.)
  • measurement of body fat and muscle mass (bioimpedance analysis)
  • blood examinations
  • oral glucose tolerance testing
  • sonography of common carotid artery
  • sonography-based liver elastography
  • 24 hour ambulatory blood pressure measurement


    How long does the participation at the study take and will there be a remuneration?

    The examinations take place over the course of one day (6h in total) and you will receive 50,-€ expense allowance.

    You are interested?

    Please do not hesitate to contact us! The study is conducted under the lead of Prof. Antje Körner and clinician scientist Dr. Robert Stein from the Department of Pediatrics.

    Tel:      +49 341 97 26922

    Email:  robert.stein@medizin.uni-leipzig.de
Liebigstraße 20a, Haus 6
04103 Leipzig
Telefon:
0341 - 97 26242 (Leitstelle)
Fax:
0341 - 97 26229
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