Inflammation in obesity

​Inflammation plays a major role in the initiation and progression of diabetes associated disorders such as chronic kidney disease and metabolic syndrome. We investigate the interplay of different molecules that are dysregulated in diabetes and obesity. With focus on the intercellular communication between endothelial and epithelial cells, we aim to decipher mechanisms of cell-cell interaction in a defined environment under static and flow conditions using microfluidic approaches. Aim is to identify novel therapeutic strategies for prevention or treatment of diabetes associated disorders.

1. ​Biemann R, Penner M, Borucki K, Westphal S, Luley C, Rönicke R, Biemann K, Weikert C, Lux A, Goncharenko N, Marschall HU, Schneider JG, Isermann B. Serum bile acids and GLP-1 decrease following telemetric induced weight loss: results of a randomized controlled trial. Sci Rep. 2016 Jul 25;6:30173.
2. Shahzad K, Bock F, Dong W, Wang H, Kopf S, Kohli S, Al-Dabet MM, Ranjan S, Wolter J, Wacker C, Biemann R, Stoyanov S, Reymann K, Söderkvist P, Groß O, Schwenger V, Pahernik S, Nawroth PP, Gröne HJ, Madhusudhan T, Isermann B. Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy. Kidney Int. 2015 Jan;87(1):74-84.
3. Eichelmann F, Schulze MB, Wittenbecher C, Menzel J, Weikert C, di Giuseppe R, Biemann R, Isermann B, Fritsche A, Boeing H, Aleksandrova K. Chemerin as a Biomarker Linking Inflammation and Cardiovascular Diseases. J Am Coll Cardiol. 2019 Jan 29;73(3):378-379. doi: 10.1016/j.jacc.2018.10.058.
4. Geserick M, Vogel M, Eckelt F, Schlingmann M, Hiemisch A, Baber R, Thiery J, Körner A, Kiess W, Kratzsch J. Children and adolescents with obesity have reduced serum bone turnover markers and 25-hydroxyvitamin D but increased parathyroid hormone concentrations - Results derived from new pediatric reference ranges. Bone. 2020 Mar;132:115124. doi: 10.1016/j.bone.2019.115124. Epub 2019 Dec 9.
5. Bae YJ, Zeidler R, Baber R, Vogel M, Wirkner K, Loeffler M, Ceglarek U, Kiess W, Körner A, Thiery J, Kratzsch J. Reference intervals of nine steroid hormones over the life-span analyzed by LC-MS/MS: Effect of age, gender, puberty, and oral contraceptives. J Steroid Biochem Mol Biol. 2019 Oct;193:105409.

​Students interested in completing their thesis or practical work in our research group should please contact ​Dr. troph. Ronald Biemann.