Inflammation in obesity

Inflammation and hormonal imbalance plays a major role in the initiation and progression of diabetes associated disorders such as chronic kidney disease and metabolic syndrome. We investigate the interplay of different molecules that are dysregulated in diabetes and obesity. With focus on the intercellular communication between endothelial and epithelial cells, we aim to decipher mechanisms of cell-cell interaction in a defined environment under static and flow conditions using microfluidic approaches. Aim is to identify novel therapeutic strategies for prevention or treatment of diabetes associated disorders.

Krishnan S, Manoharan J, Wang H, Gupta D, Fatima S, Yu Y, Mathew A, Li Z, Kohli S, Schwab C, Körner A, Mertens PR, Nawroth P, Shahzad K, Naumann M, Isermann B, Biemann R. CD248 induces a maladaptive unfolded protein response in diabetic kidney disease. Kidney Int. 2023 Feb;103(2):304-319. doi: 10.1016/j.kint.2022.09.024.

Zimmermann S, Vogel M, Mathew A, Ebert T, Rana R, Jiang S, Isermann B, Biemann R. The Extent of Lifestyle-Induced Weight Loss Determines the Risk of Prediabetes and Metabolic Syndrome Recurrence during a 5-Year Follow-Up. Nutrients. 2022 Jul 26;14(15):3060. doi: 10.3390/nu14153060.

Gupta A, Singh K, Fatima S, Ambreen S, Zimmermann S, Younis R, Krishnan S, Rana R, Gadi I, Schwab C, Biemann R, Shahzad K, Rani V, Ali S, Mertens PR, Kohli S, Isermann B. Neutrophil Extracellular Traps Promote NLRP3 Inflammasome Activation and Glomerular Endothelial Dysfunction in Diabetic Kidney Disease. Nutrients 2022, 14, 2965.

Nutrients. 2023 May 23;15(11):2429. doi: 10.3390/nu15112429.

Shahzad K, Fatima S, Khawaja H, Elwakiel A, Gadi I, Ambreen S, Zimmermann S, Mertens PR, Biemann R, Isermann B. Podocyte-specific Nlrp3 inflammasome activation promotes diabetic kidney disease. Kidney Int. 2022 Jun 30:S0085-2538(22)00513-0. doi: 10.1016/j.kint.2022.06.010.

Biemann R, Buß E, Benndorf D, Lehmann T, Schallert K, Püttker S, Reichl U, Isermann B, Schneider JG, Saake G, Heyer R. Fecal Metaproteomics Reveals Reduced Gut Inflammation and Changed Microbial Metabolism Following Lifestyle-Induced Weight Loss. Biomolecules. 2021 May 12;11(5):726. doi: 10.3390/biom11050726.​

​Students interested in completing their thesis or practical work in our research group should please contact ​Dr. troph. Ronald Biemann.