Neuroimaging Lab

Labvisit June, 2023: MRC Cognition and Brain ScienceS Unit, University of Cambridge.

Lectures, scientific exchange and the unique Cambridge atmosphere made our
​Labvisit at MRC CBSU​ in Cambridge a uniq​ue experience.
​Hosted by Prof. Matt Lambon-Ralph and Dr. Ajay Halai.​​

BRAIN Conference 2023 - Prediction of tissue outcome in stroke patients with EVT using a GLM

Brain Conference 2023 - Individualized tissue outcome prediction using convolutional neural networks

Understanding changes in connectivity after stroke.

​The Neuroimaging working group at the Neurex symposium in Freiburg, Feb 3, 2023​​

The AG Neuroimaging presents itself at the DGN Congress in Berlin​

Symposium on the topic: "Stroke - a network perspective" and poster presentation

arte X:ENIUS: How can you "simulate" a stroke?

PRESS RELEASE: SPEECH DISORDER AFTER STROKE

Post about the Neuroimaging working group

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Neuroimaging Lab
Haus am Park
Rooms: „Carl Wernicke” and “Paul Broca”, 2^nd floor
Email: Neuroimaging-Neurologie@medizin.uni-leipzig.de
Phone: +49  341 - 97 24215

​​	​Professor Dorothee Saur, MD Group Leader Phone: 0341 - 97 24243 Email:  dorothee.saur@medizin.uni-leipzig.de Room G 1008 ​ Publications: https://orcid.org/0000-0002-1808-0913
​	​Julian Klingbeil, MD Postdoc Phone: 0341 - 97 24215, -24243 Email​:  julian.klingbeil@medizin.uni-leipzig.de Room 143 „Carl Wernicke“ – Haus am Park CV Publications: https://orcid.org/0000-0002-9306-9212​
​	Sophie Marie Meixensberger, MD Postdoc Phone: 0341 - 97 24200​ Telefax: 0341 - 97 24209 Email:  Sophie.Meixensberger@medizin.uni-leipzig.de
​	​Anika Stockert, MD Postdoc Phone: 0341 - 97 24215, -24243 Email:  anika.stockert@medizin.uni-leipzig.de Room 143 „Carl Wernicke“ – Haus am Park CV Publications: https://orcid.org/0000-0001-5804-2498​
​	​​ Kristin Marie Starke, MD Postdoc Phone: 0341 - 97 24215, -24243 Email: ​​​​Kristin.Starke​@medizin.uni-leipzig.de​ Room 143 „Carl Wernicke“ – Haus am Park ​
​	​Max Wawrzyniak, MD Postdoc Phone​: 0341 - 97 24215, -24243 Email:  max.wawrzyniak@medizin.uni-leipzig.de Room 143 „Carl Wernicke“ – Haus am Park CV​​​ Publications​: https://orcid.org/0000-0002-5089-1214

Student Assistants​​

Ameli Aden, medical student​
Email: ​Ameli.Aden@medizin.uni-leipzig.de

Alexander Groos, medical student
Email: ​Alexander.Groos@medizin.uni-leipzig.de

Lenny Doberitzsch​​, medical student
Email: Lenny.Doberitzsch@medizin.uni-leipzig.de

Marcel Urbaniak, medical student
Email: Marcel.Urbaniak@medizin.uni-leipzig.de

Niklas Wiemers, medical student​
Email: Niklas.Wiemers@medizin.uni-leipzig.de

Otakhon Rustambekov​, medical student
Email: ​Otakhon.Rustambekov@medizin.uni-leipzig.de​

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• ​Multimodal neuroimaging studies of the functional neuroanatomy of cognitive brain networks and their network pathologies in neurological diseases, in particular stroke
• Longitudinal studies of the mechanisms of loss and recovery of language functions after stroke
• Development and application of methods to modulate brain networks, e. g. non-invasive brain stimulation or real-time fMRI neurofeedback
• ​Prediction of clinical and tissue outcome after stroke using machine learning methods based on multimodal neuroimaging

​​Methods​​:​

• ​Functional Magnet Resonance Imaging (fMRI) and resting-state-fMRI
• Diffusion Tensor Imaging (DTI)
• Voxel-Based Lesion Symptom Mapping (VBLSM) and Network symptom mapping
• (Multifocal) Transcranial Magnetic Stimulation(TMS)
• ​Machine learning ​

• Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig
• Day-clinic for Cognitive Neurology, University of Leipzig Medical Centre
• Institute of Neuroradiology, University of Leipzig Medical Centre
• Department for Image and Signal Processing, Institute of Computer Science, 
   University Leipzig
• Cognitive and Biological Psychology, University Leipzig
• SMITH, Smart Medical Information Technology For Healthcare
• Medical Physics, Department of Radiology, University Medical Center Freiburg
• Section for Neuropsychology, Hertie Institute for Clinical Brain Research

• ​​​Current publication lists are available via the ORCID-IDs of the working group members
• Key publications of the working group (File)

1. ​Saur D, Lange R, Baumgaertner A, Schraknepper V, Willmes K, Rijntjes M, Weiller C. Dynamics of language reorganization after stroke. Brain 2006; 129:1371-1384. https://doi.org/10.1093/brain/awl090
   

2. Saur D, Kreher BW, Schnell S, Kümmerer D, Kellmeyer P, Vry M-S, Umarova R, Musso M, Glauche V, Abel S, Huber W, Rijntjes M, Hennig J, Weiller C. Ventral and dorsal pathways for language. Proc Natl Acad Sci U S A 2008; 105(45): 18035-18040. https://doi.org/10.1073/pnas.0805234105
   

3. Saur D, Ronneberger O, Kümmerer D, Mader I, Weiller C, Klöppel, S. Early fMRI activations predict language outcome after stroke. Brain 2010; 133; 1252-1264. https://doi.org/10.1093/brain/awq021
   

4. Kümmerer D, Hartwigsen G, Kellmeyer P, Glauche V, Mader I, Klöppel S, Suchan J, Karnath HO, Weiller C, Saur D. Damage to ventral and dorsal language pathways in acute aphasia. Brain 2013; 2: 619-629. https://doi.org/10.1093/brain/aws354
   

5. Hartwigsen G, Weigel A, Schuschan P, Siebner HR, Weise D, Classen J, Saur D. Dissociating Parieto-Frontal Networks for Phonological and Semantic Word Decisions: A Condition-and-Perturb TMS Study. Cereb Cortex 2016; 26: 2590-25601. https://doi.org/10.1093/cercor/bhv092
   

6. Hartwigsen G, Bzdok D, Klein M, Wawrzyniak M, Stockert A, Wrede K, Classen C, Saur D. Rapid short-term reorganisation in the language network. eLlife 2017; 6. https://doi.org/10.7554/eLife.25964.001
   

7. Hartwigsen G., Saur D. Neuroimaging of stroke recovery from aphasia – Insights into plasticity of the human language network. Neuroimage 2019; 190: 14-31. https://doi.org/10.1016/j.neuroimage.2017.11.056
   

8. Klingbeil J, Wawrzyniak M, Stockert A, Karnath HO, Saur D. Hippocampal diaschisis contributes to anosognosia for hemiplegia: evidence from lesion network-symptom mapping. Neuroimage 2020; 208: 116485. 
   https://doi.org/10.1016/j.neuroimage.2019.116485
   

9. Stockert A, Wawrzyniak M, Klingbeil J, Wrede K, Kümmerer D, Hartwigsen G, Kaller CP, Weiller C, Saur D. Dynamics of language reorganization after left temporo-parietal and frontal stroke. Brain 2020; 143(3) 844-861.
   https://doi.org/10.1093/brain/awaa023
   

10. Hartwigsen G, Stockert A, Charpentier L, Wawrzyniak M, Klingbeil J, Wrede K, Obrig H, Saur D. Short-term modulation of the lesioned language network. eLife 2020; 9. https://doi.org/10.7554/eLife.54277
    

11. Klingbeil J, Wawrzyniak M, Stockert A, Brandt ML, Schneider HR, Metelmann M, Saur D. Pathological laughter and crying: insights from lesion network-symptom-mapping. Brain 2021; 144: 3264-3276.
    https://doi.org/10.1093/brain/awab224
    

12. Wawrzyniak M, Schneider HR, Klingbeil J, Stockert A, Hartwigsen G, Weiller C, Saur D. Resolution of diaschisis contributes to early recovery from post-stroke aphasia. Neuroimage 2022; 251:119001.
    https://doi.org/10.1016/j.neuroimage.2022.119001
    

13. Stockert A, Hormig-Rauber S, Wawrzyniak M, Klingbeil J, Schneider HR, Prilich M, Schob S, Hoffmann KT, Saur D. Involvement of thalamocortikal Networs in Patients with poststroke thalamic aphasia. Neurology, in press.
    https://doi.org/10.1212/WNL.0000000000201488
    

14. Von Braun MS, Starke K, Peter L, Kürsten D, Welle F, Schneider HR, Wawrzyniak M, Kaiser DPO, Prasse G, Richter C, Kellner E, Reisert M, Klingbeil J, Stockert A, Hoffmann KT, Scheuermann G, Gillmann C, Saur D. Prediction of tissue and clinical thrombectomy outcome in acute ischaemic stroke using deep learning. 
    Brain 2025: https://doi.org/10.1093/brain/awaf013

James S. McDonnell Foundation (JSMF): "Function, dysfunction and recovery of speech networks". 1/2012-12/2019 (PI: Dorothee Saur)

Deutsche Forschungsgemeinschaft (German Research Foundation, DFG, SA 1723/5-1): "Cognitive and neurobiological characterization of deficit awareness in post-stroke aphasia" 1/2019-12/2023 (PI: Dorothee Saur, Julian Klingbeil)​​

EU: Recanalytics –AI-based decision-support-system for acute stroke management (PI: Dorothee Saur)​

We mainly assign experimental doctoral theses, whereby a semester on leave is usually necessary during the course of the thesis. Above-average commitment and a special interest in neuroscientific work are prerequisites for acceptance as a doctoral student. Participation in the weekly doctoral seminar (see lab meeting) is expected. Here, new projects, (interim) results and publications related to the various doctoral topics are presented.

If you are interested in a medical doctoral thesis on the topics of the research group, please send an E-mail with a meaningful curriculum vitae to dorothee.saur@medizin.uni-leipzig.de​​