Molecular mechanisms linking obesity and breast cancer progression
Breast cancer is by far the most frequently diagnosed cancer in women worldwide. While many factors play a role in the formation of breast cancer (e.g. genetic disposition, smoking), obesity is now recognised as one of most important risk factors for this type of cancer, especially in post-menopausal woman. Overweight and the excess accumulation of adipose tissue not only lead to an increased incidence of breast cancer but also add to a higher mortality rate due to poor prognosis, larger tumor size and high tumor grade. In addition, a growing number of studies indicates that adipocytes associated with tumors are involved in supporting tumor progression by promoting an inflammatory and proliferatory microenvironment.
Despite an increasing body of evidence underlining the important role of adipose tissue for growth and survival of breast tumors, very little is known about the molecular mechanisms linking adipocytes and breast cancer progression. To investigate potential molecular changes in breast cancer cells induced by co-existing adipocytes we use different co-culture systems of breast cancer cells and adipose tissues.
The goal of our study is a comprehensive characterization of the interacting cell types, applying techniques such as genome-wide gene expression studies, migration and invasion assays, cell imaging and mass spectrometry.
Queries: Sonja Stadler, DSc