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Publications of Pediatric Epidemiology


Original Articles

61. Ditzhaus M, Pauly M, Genuneit J, Janssen A. CASANOVA: Permutation inference in factorial survival designs. Biometrics 2021, accepted.

60. Genuneit J, Jayasinghe S, Riggioni C, Peters R, Chu D, Munblit D, Skypala I, Du Toit G, Boyle RJ, Santos AF on behalf of the EAACI Food Allergy Guidelines Expert Group and the EAACI Research and Outreach Committee Food Allergy Group. Protocol for systematic review and meta-analysis of tests to support the diagnosis of food allergy. Pediatr Allergy Immunol 2021, accepted.

59. Blasi V, Bolognesi E, Ricci C, Baglio G, Zanzottera M, Can​evini MP, Walder M, Cabinio M, Zanette M, Baglio F, Clerici M, Guerini FR. SNAP-25 single nucleotide polymorphisms, brain morphology and intelligence in children with borderline intellectual functioning: a mediation analysis. ​ Front Neurosci 2021 Aug 4. [epub ahead of print]

​58. Munblit D, Bobko​​va P, Spiridonova E, Shihaleva A, Gamirova A, Blyuss O, Nekliudov N, Bugaeva P, Andreeva M, DunnGalvin A, Comberiati P, Apfelba​cher C, Genuneit J, Avdeev S, Kapustina V, Guekht A, Fomin A, Svistunov AA, Timashev P, Wulf Hanson S, Merson L, Carson G, Horby P, Sigfrid L, Scott JT, Semple MG, Warner JO, Vos T, Olliaro P, Glybochko P, Butnaru D and Sechenov StopCOVID Research Team. Asthma is associated with post-COVID condition in previously hospitalised adults: StopCOVID cohort study. Clin Exp Allergy 2021;9:1007-1120.​

​57. Forster F, Ege MJ,​ Gerlich J, Weinmann T, Kreißl S, Weinmayr G, Genuneit J, Nowak D, von Mutius E, Vogelberg C, Radon K. Trajectories of asthma and allergy symptoms from childhood to adulthood. Allergy 2021 Sep 2. [epub ahead of print]​

​56. Hay​ford FEA, Dolman R, Ozturk M, Nienaber A, Ricci C, L Du Toit, Brombacher F, Blaauw R, Smuts MC, Parihar SP, Malan L. Adjunct n-3 long-chain polyunsaturated fatty acid treatment in tuberculosis reduces inflammation and improves anaemia of infection more in C3HeB/FeJ mice with low than sufficient n-3 fatty acid status. Front Nutr 2021;8:550.

​55. P​​andolfini C & Ricci C, Siziba LP, Huhn S, Genuneit J & Bonati M. Intrauterine Exposures and Maternal Health Status during Pregnancy in Relation to Later Child Health: A Review of Pregnancy Cohort Studies in Europe. Int J Environ Res Public Health 2021;18:7702​.

​54. Martini ​​D, Domínguez-Perles R, Rosi A, Tassotti M, Angelino D, Medina S, Ricci C, Guy A, Oger C, Gigliotti L, Durand T, Marino M, Gottfried-Genieser H, Porrini M, Antonini M, Dei Cas A, Bonadonna RC, Ferreres F, Scazzina F, Brighenti F, Riso P, Del Bo' C, Mena P, Gil-Izquierdo A, Del Rio D. Effect of Coffee and Cocoa-Based Confectionery Containing Coffee on Markers of DNA Damage and Lipid Peroxidation Products: Results from the Pocket-4-Life Project. Nutrients 2021;13:2399.

53. Siziba LP, Brenner H, Amitay EL, Koenig W, Rothenbacher D, Genuneit J. Potential sex differences in human milk leptin and their association with asthma and wheeze phenotypes: ​Results of the Ulm Birth Cohorts. Pediatr Allergy Immunol 2021 Jun 26. [epub ahead of print]

52. Ricci C, Poulain T, Rothenbacher D, Genuneit J. Media use in association to sleep quality in German preschoolers. A mediation analysis based on the Ulm SPATZ Health Study. Nat Sci Sleep 2021;13:1025-1035.

51. Osmanov IM, Spiridonova E, Bobkova P, Gamirova A, Shikhaleva A, Andreeva M, Blyuss O, El-Taravi Y, DunnGalvin A, Comberiati P, Peroni D, Apfelbacher C, Genuneit J, Mazankova L, Miroshina A, Chistyakova E, Samitova E, Borzakova S, Bondarenko E, Korsunskiy AA, Konova I, Wulf Hanson S, Carson G, Sigfrid L, Scott JT, Greenhawt M, Whittaker EA, Garralda E, Swann O, Buonsenso D, Nicholls DE, Simpson F, Jones C, Semple MG, Warner JO, Vos T, Olliaro P, Munblit D and Sechenov StopCOVID Research Team. Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study. Eur Respir J 2021 Jul 1. [epub ahead of print]​.

50. van Sadelhoff JHJ, Siziba LP, Buchenauer L, Mank M, Wiertsema SP, Hogenkamp A, Stahl B, Garssen J, Rothenbacher D, Genuneit J. Amino acids in human milk and their associations with maternal and infant anthropometrics, infant gender, and infant health outcomes in the first years of life: The Ulm SPATZ Health Study. Nutrients 2021;13:2009.

49. Siziba LP, Stahl B, Mank M, Gonsalves J, Blijenberg B, Rothenbacher D, Genuneit J. Human milk oligosaccharide profiles over 12 months of lactation: The Ulm SPATZ Health Study. Nutrients 2021;13:1973.

48. Wiehn E & Ricci C, Alvarez-Perea A, Perkin MR, Jones CJ, Akdis C, Bousquet J, Eigenmann P, Grattan C, Apfelbacher CJ, Genuneit J. Adherence to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist in articles published in EAACI Journals: a bibliographic study. Allergy 2021 May 22. [epub ahead of print]

47. Keller W, Vogel M, Prenzel F, Genuneit J, Jurkutat A, Hilbert C, Hiemisch A, Kiess W, Poulain T. Atopic disease in children and adolescents are associated with behavioural difficulties. BMC Pediatr 2021;21:197.

46. Hose AJ, Pagani G, Karvonen AM, Kirjavainen PV, Roduit C, Genuneit J, Schmaußer-Hechfellner E, Depner M, Hazard Taft D, Kalanetra KM, Mills D, Frei R, Lauener R, Riedler J, von Mutius E, Divaret-Chauveau A, Pekkanen J, Ege MJ, and the PASTURE Study Group. Excessive meat consumption in the first year increases asth-ma risk in the PASTURE and LUKAS2 birth cohorts. Front Immunol 2021;12:651709.

45. Matterne U, Tischer C, Wang J, Knüttel, H, Genuneit J, Perkin M, Apfelbacher C. The evidence for interventions in early childhood allergy prevention – towards a living systematic review: protocol [version 2; peer review: 1 approved, 1 approved with reservations].​ F1000Research 2021;10:235.

44. Kruger HS, Pieters M, Ricci C, le Roux S, Moss SJ, Kruger IM, van Zyl T, Schutte AE. Lifestyle factors associated with the transition from healthy to unhealthy adiposity among black South African adults over 10 years. Nutr Metab Cardiovasc Dis 2021;31:2023-2032.

43. Huhn S, Escher BI, Krauss M, Scholz S, Hackermüller J, Altenburger R. Unravelling the chemical exposome in cohort studies: routes explored and steps to become comprehensive. Environ Sci Eur 2021;33.17.

​42. Paoletti G, Di Bona D, Chu D, Firinu D, Heffler E, Agache I, Jutel M, Klimek L, Pfaar O, Mosges R, DunnGalvin A, Genuneit J, Hoffmann HJ, Canonica GW. Allergen immunotherapy: the growing role of observational and randomised trial "real-world evidence". Allergy 2021;9:2663-2672.

​41. Trikamjee T, Basera W, Botha M, Facey-Thomas HE, Gaunt B, Genuneit J, Gray CL, Hadebe S, Hlela C, Kirstein F, Lunjani N, Mankahla A, Ramjith J, Levin ME. Environmental Dust Composition in Urban and Rural South Africa, and associations with Atopic Dermatitis. Pediatr Allergy Immunol 2021;32:1013-1021.​

40. Lewien C, Genuneit J, Meigen C, Kiess W, Poulain T. Sleep-Related Difficulties in Healthy Children and Adolescents. BMC Pediatr 2021;21:82.

39. Borchers NS, Santos-Valente E, Toncheva AA, Wehkamp J, Franke A, Gaertner VD, Nordkild P, Genuneit J, Jensen BAH, Kabesch M. Genetic alterations in Human β-defensin 2, which prevents atopic asthma in a mouse model, are associated with asthma and atopy in children. Front Immunol 2021;12:636061.

38. Pretorius CE, Asare H, Kruger HS, Genuneit J, Siziba LP, Ricci C. Exclusive Breastfeeding, Child Mortality, and Economic Cost in Sub-Saharan Africa. Pediatrics 2021;147:e2020030643.​

37. Ricci C, Schlarb AA, Rothenbacher D, Genuneit J. Digital media use, book reading, and aspects of sleep and sleep related fears in preschoolers: the Ulm SPATZ Health Study. Somnologie 2021, accepted​.

36. Franchini C, Rosi A, Ricci C, Scazzina F. The EnergyKids Pilot Study: Comparing Energy Balance of Primary School Children during School and Summer Camp Nutrients 2021;13:92.

35. Pieters M, Ferreira M, de Maat MPM, Ricci C. Biomarker association with cardiovascular disease and mortality - The role of fibrinogen. A report from the NHANES study. Thromb Res 2021;198:182-189.

34. Siziba LP, Lorenz L, Brenner H, Carr P, Stahl B, Mank M, Marosvölgyi T, Decsi T, Rothenbacher D, Genuneit J. Changes in human milk fatty acid composition and maternal lifestyle-related factors over a decade: a comparison between the two Ulm Birth Cohort Studies. Br J Nutr 2021;126:228-235​.

33. Krautenbacher N, Kabesch M, Horak E, Braun-Fahrländer C, Genuneit J, Boznanski A, von Mutius E, Theis F, Fuchs C, Ege MJ, and the GABRIELA and PASTURE study groups. Genetic determinants predict asthma in farm children, environmental determinants in non-farm children Pediatr Allergy Immunol 2021;32:295-304.

32. Mittermann I, Dzoro S, Gattinger P, Botha M, Basera W, Facey-Thomas HE, Gaunt B, Genuneit J, Gray C, Hlela C, Flicker S, Lunjani N, Mankahla A, Ramjith J, Valenta R, Levin ME. IgE-reactivity profiles to aeroallergen and food allergen molecules in urban and rural toddlers with and without atopic eczema in South Africa. Pediatr Allergy Immunol 2021;32:234-241.

31. Martini D, Rosi A, Tassotti M, Antonini M, Dall'Asta M, Bresciani L, Fantuzzi F, Spigoni V, Domínguez-Perles R, Angelino D, Ricci C, Del Pozo-Luengo S, Tornel PL, Scazzina F, Gil-Izquierdo A, Dei Cas A, Brighenti F, Bonadonna R, Del Rio D, Mena P. Effect of coffee and cocoa-based confectionery containing coffee on markers of cardiometabolic health: results from the pocket-4-life project. Eur J Nutr 2020 Jul 29. [epub ahead of print]

30. Braig S, Fischer N, Gonser T, Freudenmann M, Genuneit J, Kolassa IT, Rothenbacher D. [Determinants of Cognitive Development in Preschoolers - Results of the Mann-Zeichen Test]. Gesundheitswesen 2021;83:208-214.​ Article in German

29. Veit C, Weinmann T, Herrera R, Weinmayr G, Genuneit J, Windstetter D, Vogelberg C, von Mutius E, Nowak D, Radon K. Long-Term Effects of Asthma Medication on Asthma Symptoms: An Application of the Targeted Maximum Likelihood Estimation. BMC Med Res Method 2020;20:307.

28. Schlarb AA, Landwehr J, Kater M-J, Werner A, Cattarius B, Schneider B, Genuneit J, Jud A, Kolip P. When the sleep fairy's magic does not work - a critical analysis of children's book about sleep. [Wenn die Schlaffee schlecht zaubert – eine kritische Analyse der Kinderbücher zum Thema Schlafen.] Somnologie 2020;24:229-36. Article in German

27. Depner M, Hazard Taft D, Kirjavainen PK, Kalanetra KM, Karvonen AM, Peschel S, Schmausser-Hechfellner E, Roduit C, Frei R, Lauener R, Divaret-Chauveau A, Dalphin J-C, Riedler J, Roponen M, Kabesch M, Renz H, Pekkanen J, Farquharson FM, Louis P, Mills D, von Mutius E, PASTURE study group, Ege MJ. Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma. Nat Med 2020;26:1766-1775.

26. Ricci C, Parra-Robledo Z, Rothenbacher D, Díaz-Morales JF, Genuneit J. Parent's chronotype and child sleeping quality in association with relationship satisfaction. A triadic approach in the Ulm SPATZ Health Study. Clocks & Sleep 2020;2:375-389.

25. Rosi A, Biasini B, Donati M, Ricci C, Scazzina F. Adherence to the Mediterranean Diet and Environmental Impact of the Diet on Primary School Children Living in Parma (Italy). Int J Environ Res Public Health 2020;17:6105.

24. Hayford FEA, Dolman RC, Blaauw R, Nienaber A, Smuts CM, Malan L, Ricci C. The effects of anti-inflammatory agents as host-directed adjunct treatment of tuberculosis in humans: a systematic review and meta-analysis. Respir Res 2020;21:223.

23. Nekliudov NA, Blyuss O, Cheung KY, Petrou L, Genuneit J, Suchentsev N, Levadnaya A, Comberiati P, Warner JO, Tudor-Williams G, Teufel M, Greenhawt M, Dunn Galvin A, Munblit D. Excessive media consumption about COVID-19 is associated with increased state anxiety: Outcomes of a large online survey in Russia. J Med Internet Res 2020;22:e20955.

22. Stoffel NU, Uyoga MA, Mutuku FM, Frost JN, Mwasi E, Paganini D, van der Klis FRM, Malhotra IJ, LaBeaud AD, Ricci C, Karanja S, Drakesmith H, King CH, Zimmermann MB. Iron Deficiency Anemia at Time of Vaccination Predicts Decreased Vaccine Response and Iron Supplementation at Time of Vaccination Increases Humoral Vaccine Response: A Birth Cohort Study and a Randomized Trial Follow-Up Study in Kenyan Infants. Front Immunol 2020;11:1313.

21. Carboo JA, Lombard M, Conradie C, Dolman RC, Ricci C. Evaluation of the treatment guidelines, practices and outcomes of complicated severe acute malnutrition in children aged 0-59 months in sub-Saharan Africa: a study protocol for the SAMAC study. Pan Afr Med J 2020;36:241.

20. Carboo JA, Asare Hm, Nel E, Ricci C, Lombard M, Dolman R. Treatment outcomes and determinants of mortality in children aged 0-59 months diagnosed with complicated severe acute malnutrition in two referral hospitals in Ghana. Vulnerable Children and Youth Studies 2020;15:329-43.

19. Ricci C, Leitzmann MF, Freisling H, Schutte AE, Schutte R, Kruger SH, Smuts CM, Pieters M. Diet and sedentary behaviour in relation to mortality in US adults with a cardiovascular condition: results from the National Health and Nutrition Examination Survey linked to the US mortality registry. Br J Nutr 2020;124:1329-37.

18. Pretorius CE, Asare H, Genuneit J, Kruger HS, Ricci C. Impact of Breastfeeding on Mortality in Sub-Saharan Africa: A Systematic Review and Meta-Analysis. Eur J Pediatr 2020;179:1213-1225.

17. Ricci C, Freisling H, Leitzmann MF, Taljaard-Krugell C, Jacobs I, Kruger HS, Smuts CM, Pieters M. Diet and sedentary behaviour in relation to cancer survival. A report from the national health and nutrition examination survey linked to the U.S. mortality registry. Clin Nutr 2020;39:3489-96.

16. Malan L, Smuts CM, Baumgartner J, Ricci C. Missing data imputation via the expectation-maximization algorithm can improve principal component analysis aimed at deriving biomarker profiles and dietary patterns. Nutr Res 2020;75:67-76.

15. Ricci C, Schutte AE, Schutte R, Smuts CM, Pieters M. Trends in alcohol consumption in relation to cause-specific and all-cause mortality in the United States: a report from the NHANES linked to the US mortality registry. Am J Clin Nutr 2020;111:580-9.

14. Preez GD, Fourie H, Daneel M, Miller H, Höss S, Ricci C, Engelbrecht G, Zouhar M, Wepener V. Oxygen consumption rate of Caenorhabditis elegans as a high-throughput endpoint of toxicity testing using the Seahorse XF e 96 Extracellular Flux Analyzer. Sci Rep 2020;10:4239.

13. Siziba LP, Lorenz L, Stahl B, Mank M, Marosvölgyi T, Decsi T, Rothenbacher D, Genuneit J. Human milk fatty acid composition of allergic and non-allergic mothers: The Ulm SPATZ Health Study. Nutrients 2020;12:1740.

12. Moscato G, Apfelbacher C, Brockow K, Eberle C, Genuneit J, Mortz CG, Quecchia C, Quirce S, Siracusa A, Tarlo SM, van Kampen V, Walusiak-Skorupa J, Raulf M. GENDER AND OCCUPATIONAL ALLERGY (GOA): Report from the task force of the EAACI Environmental & Occupational Allergy Interest Group. Allergy 2020;75:2753-63.

11. Braig S, Logan CA, Reister F, Rothenbacher D, Genuneit J. Psychosocial stress and longitudinally measured gestational weight gain throughout pregnancy: The Ulm SPATZ Health Study. Sci Rep 2020;10:1996.

10. Kolberg L, Forster F, Gerlich J, Weinmayr G, Genuneit J, Windstetter D, Vogelberg C, von Mutius E, Nowak D, Radon K. Nickel allergy is associated with respiratory symptoms in young German adults. ERJ Open Res 2020;6:00178-2019.

9. Rekima A, Bonnart C & Metcalfe J, Macchiaverni P, Tulic MK, Halloin N, Genuneit J, Zanelli S, Medeiros S, Palmer DJ, Prescott S, Verhasselt V. A role for early oral exposure to house dust mite allergens through breastmilk in food allergy susceptibility. J Allergy Clin Immunol 2020;145:1416-1429.e11

8. Verhasselt V, Genuneit J, Metcalfe JR, Tulic MK, Rekima A, Palmer DJ, Prescott SL. Ovalbumin in breastmilk is associated with a decreased risk of IgE-mediated egg allergy in children. Allergy 2020;75:1463-1466.

7. Levin ME, Botha M, Basera W, Facey-Thomas HE, Gaunt B, Gray CL, Kiragu W, Ramjith J, Watkins A, Genuneit J. Environmental factors associated with allergy in urban and rural children from the South AFrican Food Allergy (SAFFA) cohort. J Allergy Clin Immunol 2020;145:415-426.

6. Siziba LP, Lorenz L, Stahl B, Mank M, Marosvölgyi T, Decsi T, Rothenbacher D, Genuneit J. Changes in human milk fatty acid composition during lactation: The Ulm SPATZ Health Study. Nutrients 2019;11:2842.

5. Brick T, Hose A, Wawretzka K, von Mutius E, Roduit C, Lauener R, Riedler J, Karvonen AM, Pekkanen J, Divaret-Chauveau A, Dalphin JC, Ege MJ; PASTURE study group. Parents know it best: prediction of asthma and lung function by parental perception of early wheezing episodes. Pediatr Allergy Immunol 2019;30:795-802.

4. Logan CA, Siziba LP, Koenig W, Carr P, Brenner H, Rothenbacher D, Genuneit J. Leptin in human breast milk and child body mass index: Results of the Ulm Birth Cohort Studies. Nutrients 2019;11:1883.

3. Gramß M, Lipek T, Vogel M, Remmler J, Hiemisch A, Jurkutat A, Genuneit J, Körner A, Kiess W. Overweight-proxies are associated with atopic asthma - a matched case-control study. Horm Res Paediatr 2019;91:380-390.

2. Weinmann T, Forster F, von Mutius E, Vogelberg C, Genuneit J, Windstetter D, Nowak D, Radon K, Gerlich J. Association between occupational exposure to disinfectants and asthma in young adults working in cleaning or health services – results from a cross-sectional analysis in Germany. J Occup Environ Med 2019;61:754-759.

1. Botha M, Basera W, Facey-Thomas HE, Genuneit J, Gray CL, Kiragu W, Lunjani N, Ramjith J, Watkins A, Levin M. Nutrition and allergic diseases in urban and rural communities from the South African Food Allergy (SAFFA) cohort. Pediatr Allergy Immunol 2019;30:511-521.​

Editorials & Opinion Pieces

1. Boyle RJ, Genuneit J. Hydrolysed for​mula and allergy prevention. Pediatr Allergy Immunol 2021;32:667-9​.​

Books and book chapters

4. Genuneit J, Standl M. Epidemiology of Allergy: Natural Course and Risk Factors of Allergic Diseases. Handb Exp Pharmacol 2021 Jun 25. [epub ahead of print]

3. Genuneit J, Mösges R, Ollert M. Epidemiology, Registries, Big Data. In: Agacha I (Eds.). White Paper on Research, Innovation and Quality Care. ​European Academy of Allergy and Clinical Immunology, Zürich. 2018

2. Genuneit J. How to deal with proxy-reports? In: Kiess W, Bornehag C-G, Gennings C (Eds.). Pediatric and Adolescent Medicine, Vol. 21. Pediatric Epidemiology. Karger, Basel. 2018

1. Genuneit J. How to deal with confounders? In: Kiess W, Bornehag C-G, Gennings C (Eds.). Pediatric and Adolescent Medicine, Vol. 21. Pediatric Epidemiology. Karger, Basel. 2018

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