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Memory / working memory

Guidelines Diagnostics and therapy of memory disorders

​Guidelines Diagnostics and therapy of memory disorders

Contact: Dr. A. Thöne-Otto (

External Cooperation: Ackermann, H. (University of Tübingen, Deutsche Gesellschaft für Neuroloigsche Rehabilitation DGNR); Benke, T. (Österreichische Neurologische Gesellschaft); Hildbrandt, H. (University of Oldenburg); Hoffmann, C. (Deutscher Verband Ergothearpie DVE); Müller, S.V. (Ostfalia University); Nyffeler, T. (Schweizer Neurologische Gesellschaft); Wallesch, C. (Deutsche Gesellschaft für Neurologie DGN)

Systematic literature research and evaluation for evidence-based guidelines in neuropsychological diagnostics and therapy in the treatment of memory disorders.

Duration: 01/2018 - 12/2019

Financing: Internal budget / Society for Neuropsychology

Adaptive working memory training

​Evaluation of an adaptive working memory training program for patients with brain lesions

Contact: Dr. A. Thöne-Otto (, DP J. Weicker (, DP N. Hudl (MPI), PD Dr. K. Müller (MPI), Dr. J. Lepsien (MPI)

External Cooperation: I. Heyroth, HASOMED GmbH, Magdeburg

The aim of the study was the development and evaluation of an adaptive, theoretical, working memory training intervention. In cooperation with HASOMED GmbH, "WOME" was developed and evaluated in a randomized-controlled, double-blind, clinical trial 0with 60 healthy elderly adults and 40 patients with acquired brain lesions. The working memory training condition was compared to a control intervention with low working memory requirements. WOME led to significant improvements in subjective functionality in everyday life. However, improvements in standardized neuropsychological measures were only observed in healthy subjects.

Duration: 01.02.2011 - 31.12.2018

Financing: MPI for Human Cognitive and Brain Sciences, Max-Net-Aging

Computer-aided working memory training

​Investigation of specificity and dose effects of computer-aided working memory training in patients after brain injury

Contact: Dr. A. Thöne-Otto (, MA M. Schwarzer, DP J. Weicker (, DP N. Hudl (MPI)

External cooperation: Prof. H. Hildebrandt, University of Oldenburg

The aim of the study was to investigate the efficacy of working memory training compared to non-specific attention training. In addition, the importance of training intensity was analyzed. Twenty patients with acquired brain damage received either specific working memory training or non-specific attention training in a double-blind, randomized, controlled trial. The effectiveness of working memory training was not superior to that of non-specific attention training. Both led to increased performance in untrained working memory tasks, in verbal memory, and in the self-assessment of everyday performance. The results show that 10 training sessions were not sufficient to induce transfer effects and that a training dose of 20 sessions would be necessary for such effects.

Duration: 27.06.2016 - 31.12.2018

Financing: Internal Budget

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