​​​​​​​​​​​​​​​​​​​​​​​​​​​​Publikationen (peer-reviewed)​​​​​

  1. Mahmoud DB, Woelk C, Schulz-Siegmund M. Fabrication of 3d Printed, Core-and-Shell Implants as Controlled Release Systems for Local Sirna Delivery. Adv Healthc Mater. 2023 Sep 15:e2301643. doi: 10.1002/adhm.202301643​.

  2. Wenzel B, Schmid M, Teodoro R, Moldovan RP, Lai TH, Mitrach F, Kopka K, Fischer B, Schulz-Siegmund M, Brust P, Hacker MC. Radiofluorination of an Anionic, Azide-Functionalized Teroligomer by Copper-Catalyzed Azide-Alkyne Cycloaddition. Nanomaterials (Basel). 2023 Jul 18;13(14):2095. doi: 10.3390/nano13142095​​.

  3. Roerig J, Schulz-Siegmund M. Standardization Approaches for Extracellular Vesicle Loading with Oligonucleotides and Biologics. Small 2023, 2301763. doi: 10.1002/smll.202301763​​.

  4. Gross G, Schmohl L, Fuchs F, Guenther E, Schulz-Siegmund M, Schoengart J, Hahnel S, Koenig A. Retention force, translucency, and microstructural properties of translucent . temporary luting cements: An in vitro study. Journal of the Mechanical Behavior of Biomedical Materials 2023, 142, 105781. doi:​​​.

  5. Vejjasilpa K, Maqsood I, Schulz-Siegmund M, Hacker MC. Adjustable Thermo-Responsive, Cell-Adhesive Tissue Engineering Scaffolds for Cell Stimulation through Periodic Changes in Culture Temperature. PMID: 36614014 PMCID: PMC9820143​​. doi: 10.3390/ijms24010572​.

  6. Mahmoud DB, Schulz-Siegmund M. Utilizing 4D Printing to Design Smart Gastroretentive, Esophageal, and Intravesical Drug Delivery Systems. Adv Healthc Mater. 2022 Dec 26:e2202631, PMID: 36571721​. doi: 10.1002/adhm.202202631​.​

  7. Roerig J, Mitrach F, Schmid M, Hause G, Hacker MC, Wölk C, Schulz-Siegmund MSynergistic siRNA Loading of Extracellular Vesicles Enables Functional Delivery into Cells. PMID: 36284470;  doi10.1002/smtd.202201001​.​

  8. Giselbrecht J, Pinnapireddy S, Alioglu F, Sami H, Sedding D, Erdmann F, Janich H, Schulz-Siegmund M, Ogris M, Bakowsky U, Langner A, Bussmann J, Wölk CInvestigating 3R In Vivo Approaches for Bio-Distribution and Efficacy Evaluation of Nucleic Acid Nanocarriers: Studies on Peptide-Mimicking Ionizable Lipid. PMID: 35355412 ​; doi10.1002/smll.202107768.

  9. Hinkelmann S, Springwald AH,  Schulze S, Hempel U, Mitrach F, Wölk C, Hacker MC, Schulz-Siegmund M.  Mineralizing Gelatin Micro particles as Cell C arrier and Drug Delivery System for siRNA for Bone Tissue Engineering. Pharmaceutics 2022, 14(3), 548; doi:10.3390/pharmaceutics10430548.​​​  ​

  10. Mitrach F, Schmid M, Toussaint M, Dukic-Stefanovic S, Deuther-Conrad W, Franke H, Ewe A, Aigner A, Wölk C, Brust P, Hacker MC, Schulz-Siegmund M. Amphiphilic Anionic Oligomer-Stabilized Calcium Phosphate Nanoparticles with Prospects in siRNA Delivery via Convection-Enhanced Delivery. Pharmaceutics 2022, 14(2), 326; doi:10.3390/pharmaceutics14020326 .​

  11. ​​Hinkelmann S, Springwald AH, Starke A, Kalwa H, Wölk C, Hacker MC, Schulz-Siegmund M., Microtissues from mesenchymal stem cells and siRNA-loaded cross-linked gelatin microparticles for bone regeneration. eCollection 2022 Jan. PMID: 34988418. Mater Today Bio. 2021 Dec 17;13:100190. doi: 10.1016/j.mtbio.2021.100190,  doi: 10.1016/j.mtbio.2021.100190 .​
  12. Krieghoff J, Gronbach M, Schulz-Siegmund M, Hacker MC. Biodegradable macromers for implant bulk and surface engineering. Biol Chem. 2021 Aug 24;402(11):1357-1374. Print 2021 Oct 26. PMID: 34433237 doi: 10.1515/hsz-2021-016 .

  13. Li H, Nawaz HA, Masieri FF, Vogel S, Hempel U, Bartella AK, Zimmerer R, Simon JC, Schulz-Siegmund M, Hacker M, Lethaus B, Savković V. Osteogenic Potential of Mesenchymal Stem Cells from Adipose Tissue, Bone Marrow and Hair Follicle Outer Root Sheath in a 3D Crosslinked Gelatin-Based Hydrogel.
    Int J Mol Sci. 2021 May 20;22(10):5404. PMID: 34065598 doi:10.3390/ijms22105404 .
  14. Krieghoff J, Rost J, Kohn-Polster C, Müller BM, Koenig A, Flath T, Schulz-Siegmund M, Schulze FP, Hacker MC Extrusion-Printing of Multi-Channeled Two-Component Hydrogel Constructs from Gelatinous Peptides and Anhydride-Containiing Oligomers. Biomedicines 2021; 9(4): 1-22 ISSN 2227-9059, doi:10.3390/biomedicines9040370 ​.

  15. Nawaz HA, Schröck K, Schmid M, Krieghoff J, Maqsood I, Kascholke C, Kohn-Polster C, Schulz-Siegmund M, Hacker MC Injectable oligomer-cross-linked gelatine hydrogels via anhydride-amine-conjugation. J Mater Chem B 2021; 9(9): 2295-2307 ISSN 2050-750X, doi:10.1039/d0tb02861d .

  16. Roerig J, Schiller L, Kalwa H, Hause G, Vassiennon C, Hacker MC, Wölk C, Schulz-Siegmund M A focus on critical aspects of uptake and transport of milk-derived extracellular vesicles across the Caco-2 intestinal barrier model. Eur J Pharm Biopharm 2021; 166: 61-74 ISSN 0939-6411, doi: 10.1016/j.ejpb.2021.05.026 .​
  17. Schulz-Siegmund M, Aigner A Nucleic acid delivery with extracellular vesicles. Adv Drug Deliv Rev 2021; 173(): 89-111 ISSN 0169-409X, doi:10.1016/J.ADDR.2021.03.005 .

  18. Amin MU, Ali S, Ali MY, Tariq I, Nasrullah U, Pinnapreddy SR, Wölk C, Bakowsky U, Brüßler J Enhanced efficacy and drug delivery wiht lipid coated mesoporous silica nanoparticles in cancer therapy Eur J Pharm Biopharm 2021; 165: 31-40 ISSN 0939-6411, doi:10.1016.j.ejpb.2021.04.020.

  19. Koenig A, Schmidtke J, Schmohl L, Schneider-Feyrer S, Rosentritt M, Hoelzig H, Kloess G, Vejjasilpa K, Schulz-Siegmund M, Fuchs F, Hahnel S Characterisation of the Filler Fraction in CAD/CAM Resin-Based Composites. Materials (Basel) 2021; 14(8): 1-15 ISSN 1996-1944, doi:10.3390/ma14081986 .​

  20. Koenig A, Schmohl L, Scheffler J, Fuchs F, Schulz-Siegmund M, Doerfler HM, Jankuhn S, Hahnel S Is Miccro X-ray Computer Tomography a Suitable Non-Destructive Method for the Characterisation of Dental Materials? Polymers (Basel) 2021; 13(8): 1-13 ISSN 2073-4360, doi:10.3390/polym13081271 .​

  21. Rehal R, Barker RD, Lu Z, Bui TT, Demé B, Hause G, Wölk C, Harvey RD Lipid domain formation and non-lamellar structures associated with varied lysylphosphatidyglycerol analogue content in a model Staphylococcal plasma membrane. ISSN 0005-2736Biochim Biophys Acta Biomembr 2021; 1863(5): 183571 ISSN 0005-2736, doi:10.1016/j.bbamem.2021.183571 .

  22. Kuzmenka D, Sewohl C, König A, Flath T, Hahnel S, Schulze FP, Hacker MC, Schulz-Siegmund M. Sustained Calcium(II)-Release to Impart Bioactivity in Hybrid Glass Scaffolds for Bone Tissue Engineering. Pharmaceutics. 2020 Dec 8;12(12):E1102. doi:10.3390/pharmaceutics12121192 . PMID: 33302527 .​

  23. Gronbach M, Mitrach F, Möller S, Rother S, Friebe S, Mayr SG, Schnabelrauch M., Hintze V, Hacker MCSchulz-Siegmund M, A Versatile Macromer-Based Glycosaminoglycan (sHA3) Decorated Biomaterial for Pro-Osteogenic Scavenging of Wnt Antagonists, 2020, 12, 1037. doi:10.3390/pharmaceutics12111037 .

  24. Wölk CNawaz H AMaqsood I, Strati F, Brezesinski G, Hause G, Schulz-Siegmund M, and Hacker MC, Amphiphilic Functionalized Oligomers: A PromisingStrategy for the Postfabrication Functionalization of Liposomes. Advanced Materials Interfaces, 2020, accepted. Adv. Mater. Interfaces 2020, 7, 2001168, doi: 10.1002/admi.202001168 .

  25. Gronbach M, Mitrach F, Lidzba V, Müller B, Möller S, Rother S, Salbach-Hirsch J, Hofbauer L C, Schnabelrauch M, Hintze V, Hacker MCSchulz-Siegmund M, Scavenging of Dickkopf-1 by macromer-based biomaterials covalently decorated with sulfated hyaluronan displays pro-osteogenic effects, Acta Biomaterialia, 2020, 114, 76-89. doi:10.1016/j.actbio.2020.07.017 .​

  26. Krieghoff J, Picke AK, Salbach-Hirsch J, Rother S, Heinemann C, Bernhardt R, Kascholke C, Möller S, Rauner M, Schnabelrauch M, Hintze V, Scharnweber D, Schulz-Siegmund M, Hacker MC, Hofbauer LC, Hofbauer C, Increased pore size of scaffolds improves coating efficiency with sulfated hyaluronan and mineralization capacity of osteoblasts. Biomater Res., 2019; 23:26.

  27. Walker S, Schönfelder J, Tugtekin SM, Wetzel C, Hacker MCSchulz-Siegmund M. Stabilization and Sterilization of Pericardial Scaffolds by Ultraviolet and Low-Energy Electron Irradiation. 2018; 24(12):717-729.  doi:10.1089/ten.TEC.2018.0285 ​.​

  28. Schulze J, Kuhn S, Hendrikx SSchulz-Siegmund M, Polte T, Aigner A. Spray-Dried Nanoparticle-in-Microparticle Delivery Systems (NiMDS) for Gene Delivery, Comprising Polyethylenimine (PEI)-Based Nanoparticles in a Poly(Vinyl Alcohol) Matrix. 2018; 14(12):e1701810. doi:10.1002/smll.201701810 .

  29. Kascholke C, Hendrikx S, Flath T, Kuzmenka D, Dörfler HM, Schumann D, Gressenbuch M, Schulze FP, Schulz-Siegmund M, Hacker MC. Biodegradable and adjustable sol-gel glass based hybrid scaffolds from multi-armed oligomeric building blocks. Acta Biomater. 2017;63:336-349. doi: 10.1016/j.actbio.2017.09.024 ​.​

  30. Kohn-Polster C, Bhatnagar D, Woloszyn DJ, Richtmyer M, Starke A, Springwald AH, Franz S, Schulz-Siegmund M, Kaplan HM, Kohn J, Hacker MC. Dual-Component Gelatinous Peptide/Reactive Oligomer Formulations as Condult Material and Luminal Filler for Peripheral Nerve Regeneration. Free PMC Article. 2017. doi: 10.3390/ijms18051104 .

  31. Schwabe, K, Ewe, A, Kohn, C, Loth, T, Aigner, A, Hacker, MC, Schulz-Siegmund, M. Sustained delivery of siRNA poly- and lipopolyplexes from porous macromer-crosslinked gelatin gels. Int. J. Pharm. 2017 (accepted). doi: 10.1016/j.ijpharm.2017.04.065 .​

  32. Hendrikx S, Kuzmenka, D, Köferstein, R, Flath T, Uhlig, H, Enke, D, Schulze P, Hacker MC, Schulz-Siegmund M. Effects of curing and organic content on bioactivity and mechanical properties of hybrid sol-gel glass scaffolds made by indirect rapid prototyping. Journal of Sol-Gel Science and Technology. 2017 (accepted).

  33. Kascholke C, Loth T, Kohn-Polster C, Möller S, Bellstedt P, Schulz-Siegmund M, Schnabelrauch M, Hacker MC. Dual-Functional Hydrazide-Reactive and Anhydride-Containing Oligomeric Hydrogel Building Blocks. Biomacromolecules. 2017;18(3):683-694. doi: 10.1021/acs.biomac.6b01355 .​

  34. Müller BM, Loth R, Hoffmeister PG, Zühl F, Kalbitzer L, Hacker MC, Schulz-Siegmund M. Surface modification of copolymerized films from three-armed biodegradable macromers - an analytical platform for modified tissue engineering scaffolds. Acta Biomater. 2017;51:148-160. doi: 10.1016/j.actbio.2017.01.018

  35. Sülflow K, Schneider M, Loth T, Kascholke C, Schulz-Siegmund M, Hacker MC, Simon JC, Savkovic V. Melanocytes from the outer root sheath of human hair and epidermal melanocytes display improved melanotic features in the niche provided by cGEL, oligomer-cross-linked gelatin-based hydrogel. J Biomed Mater Res A. 2016;104(12):3115-3126. doi: 10.1002/jbm.a.35832

  36. Schulze J, Hendrikx S, Schulz-Siegmund M, Aigner A. Microparticulate poly(vinyl alcohol) hydrogel formulations for embedding and controlled release of polyethylenimine (PEI)-based nanoparticles. Acta Biomater. 2016;45:210-222. doi: 10.1016/j.actbio.2016.08.056

  37. Kohn C, Klemens JM, Kascholke C, Murthy NC, Kohn J, Brandenburger M, Hacker MC. Dual-component collagenous peptide/reactive oligomer hydrogels as potential nerve guidance materials – from characterization to functionalization. Biomater Sci. 2016;4(11):1605-1621. doi: 10.1039/c6bm00397d

  38. Sedaghati B, Jahroomishirazi R, Starke A, C. Hacker M, Schulz-Siegmund M. Rat osteosarcoma cells as a therapeutic target model for osteoregeneration via sclerostin knockdown, Cells Tissues Organs 2016;201(5):366-379. doi: 10.1159/000444634

  39. Picke AK, Salbach-Hirsch J, Hintze V, Rother S, Rauner M, Kascholke C, Möller S, Bernhardt R, Rammelt S, Pisabarro MT, Ruiz-Gómez G, Schnabelrauch M, Schulz-Siegmund M, Hacker MC, Scharnweber D, Hofbauer C, Hofbauer LC. Sulfated hyaluronan improves bone regeneration of diabetic rats by binding sclerostin and enhancing osteoblast function. Biomaterials. 2016;96:11-23. doi: 10.1016/j.biomaterials.2016.04.013

  40. Hendrikx S, Kascholke C, Flath T, Schumann D, Gressenbuch M, Schulze P, Hacker MC, Schulz-Siegmund M. Indirect rapid prototyping of sol-gel hybrid glass scaffolds for bone regeneration - effects of organic crosslinker valence, content and molecular weight on mechanical properties. Acta Biomater. 2016;35:318-329. doi: 10.1016/j.actbio.2016.02.038

  41. Hacker MC, Nawaz HA. Multi-functional Macromers for Hydrogel Design in Biomedical Engineering and Regenerative Medicine. Int J Mol Sci. 2015;16(11):27677-27706. doi: 10.3390/ijms161126056

  42. Roßteuscher-Carl K, Fricke S, Hacker MC, Schulz-Siegmund M. Influence of in line monitored fluid bed granulation process parameters on the stability of Ethinylestradiol, Int J Pharm. 2015;496(2):751-758. doi: 10.1016/j.ijpharm.2015.10.074

  43. Loth R, Loth T, Schwabe K, Bernhardt R, Schulz-Siegmund M, Hacker MC. Highly adjustable biomaterial networks from three-armed biodegradable macromers. Acta Biomater. 2015;26:82-96. doi: 10.1016/j.actbio.2015.08.008

  44. Savkovic V, Flämig F, Schneider M, Sülflow K, Loth T, Lohrenz A, Hacker MC, Schulz-Siegmund M, Simon J-C. Polycaprolactone fiber meshes provide a 3D environment suitable for cultivation and differentiation of melanocytes from the outer root sheath of hair follicle, J Biomed Mater Res A. 2016;104(1):26-36. doi: 10.1002/jbm.a.35536

  45. van der Smissen A, Hoffmeister PG, Friedrich N, Watarai A, Hacker MC, Schulz-Siegmund M, Anderegg U. Artificial extracellular matrices support cell growth and matrix synthesis of human dermal fibroblasts in macroporous 3D scaffolds. J Tissue Eng Regen Med. 2015. doi: 10.1002/term.2037

  46. Jahroomishirazi R, Bader A, Ebert S, Schmidt C, Sedaghati B, Schulz-Siegmund M, Zscharnack M. Isolation and Characterization of CD271+ Stem Cells Derived from Sheep Dermal Skin. Cells Tissues Organs. 2014;200(2):141-152. doi: 10.1159/000381534

  47. Schröck K, Lutz J, Mändl S, Hacker MC, Kamprad M, Schulz-Siegmund M. Co(II)-mediated effects of plain and PIII-modified cobalt-chromium alloys on the osteogenic differentiation of human mesenchymal stem cells, J Orthop Res. 2015;33(3):325-333. doi: 10.1002/jor.22765

  48. Schwarz S, Huss R, Schulz-Siegmund M, Vogel B, Brandau S, Lang S, Rotter N. Bone-marrow derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion. International Journal of Oral Science. 2014;6(3):154-161. doi: 10.1038/ijos.2014.23

  49. Loth T, Hötzel R, Kascholke C, Anderegg U, Schulz-Siegmund M, Hacker MC. Gelatin-based biomaterial engineering with anhydride-containing oligomeric cross-linkers. Biomacromolecules 2014;15:2104-2118. doi: 10.1021/bm500241y

  50. Steinhagen M, Hoffmeister PG, Nordsieck K, Hötzel R, Baumann L, Hacker M, Schulz-Siegmund M, Beck-Sickinger A. Matrix Metalloproteinase 9 (MMP-9) Mediated Release of MMP-9 Resistant Stromal Cell-Derived Factor 1α (SDF-1α) from Surface Modified Polymer Films, Applied Materials and Interphaces 6. 2014;5891-5899. doi: 10.1021/am500794q

  51. Roßteuscher-Carl K, Fricke S, Hacker MC, Schulz-Siegmund M. In-line monitoring of particle size in a fluid bed granulator: Investigations concerning positioning and configuration of the sensor. Int J Pharm. 2014;466(1-2):31-37. doi: 10.1016/j.ijpharm.2014.02.044

  52. Rotter N, Schwarz S, Huss R, Schulz-Siegmund M, Vogel B, Branda, S, Lang S. Bone-marrow derived mesenchymal stem cells migrate to healthy and damaged salivary glands following stem cell infusion. International Journal of Oral Science. 2014;6:154–161. doi: 10.1038/ijos.2014.23

  53. Schneider H, Sedaghati B, Naumann A, Hacker MC, Schulz-Siegmund M. Gene silencing of chordin improves BMP-2 effects on osteogenic differentiation of human adipose tissue-derived stromal cells. Tissue Eng Part A. 2014;20(1-2):335-345. doi: 10.1089/ten.TEA.2012.0563

  54. Wei R, Oeser T, Barth M, Weigl N, Lübs A, Schulz-Siegmund M, Hacker MC, Zimmermann W. Turbidimetric analysis of the enzymatic hydrolysis of polyethylene terephthalate nanoparticles. J. Mol. Catal. B: Enzym. 2014;103:72-78. doi: 10.1016/j.molcatb.2013.08.010

  55. Schröck K, Schneider H, Lutz J, Hacker MC, Mändl S, Kamprad M, Schulz-Siegmund M. Cytocompatibility of nitrogen plasma ion immersed medical cobalt-chromium alloys. J Biomed Mater Res A. 2014;102(6):1744-1754. doi: 10.1002/jbm.a.34842

  56. Mai M, Hempel U, Hacker MC, Dieter P. Effects of HyStem (TM)-HP Hydrogel Elasticity on Osteogenic Differentiation of Human Mesenchymal Stromal Cells. Cell Mol Bioeng. 2014;7:155-164. doi: 10.1007/s12195-013-0314-7

  57. Loth T, Hennig R, Kascholke C, Hötzel R, Hacker MC. Reactive and stimuli-responsive maleic anhydride containing macromers – multi-functional cross-linkers and building blocks for hydrogel fabrication. React Funct Polym. 2013;73:1480-1492. doi: 10.1016/j.reactfunctpolym.2013.08.002

  58. Hoyer J, Schatzschneider U, Schulz-Siegmund M, Neundorf I. Dimerization of a cell-penetrating peptide leads to enhanced cellular uptake and drug delivery. Beilstein J Org Chem. 2012;8:1788-97. doi: 10.3762/bjoc.8.204

  59. Penk A, Förster Y, Scheidt HA, Nimptsch A, Hacker MC, Schulz-Siegmund M, Ahnert P, Schiller J, Rammelt S, Huster D. The pore size of PLGA bone implants determines the de novo formation of bone tissue in tibial head defects in rats. 2013;70(4):925-935. doi: 10.1002/mrm.24541

  60. Hassert R, Hoffmeister PG, Pagel M, Hacker M, Schulz-Siegmund M, Beck-Sickinger AG. On-Resin Synthesis of an Acylated and Fluorescence-Labeled Cyclic Integrin Ligand for Modification of Poly(lactic-co-glycolic acid). Chemistry & Biodiversity. 2012;9:2648-2658. doi: 10.1002/cbdv.201200290

  61. Pavlica S, Schmitmeier S, Gloeckner P, Piscioneri A, Peinemann F, Krohn K, Siegmund-Schulz M, Laera S, Favia P, Bartolo L de, Bader A. Effect of native and NH3 plasma-functionalized polymeric membranes on the gene expression profiles of primary hepatocytes. J Tissue Eng Regen Med. 2012;6:486-496. doi: 10.1002/term.453

  62. Weber F, Böhme J, Scheidt HA, Gründer W, Rammelt S, Hacker, M, Schulz-Siegmund M, Huster D. 31P and 13C Solid-State NMR Spectroscopy to Study Collagen Synthesis and Biomineralization in Polymer-Based Bone Implants. NMR in Biomedicine. 2012;25:464-475. doi: 10.1002/nbm.1649

  63. Ambrosch K, Mannhardt M, Loth T, Bernhard R, Schulz-Siegmund MHacker, MC. Open Porous Microscaffolds for Cellular and Tissue Engineering by Lipid Templating. Acta Biomaterialia. 2012;8:1303-1315. doi: 10.1016/j.actbio.2011.11.020

  64. Böhme J, Anderegg U, Nimptsch A, Nimptsch K, Hacker M, Schulz-Siegmund M, Huster D, Schiller J. De novo biosynthesis of GAG in the extracellular matrix of skin studied by MALDI MS, Analytical Biochemistry. 2012;421:791-93. doi: 10.1016/j.ab.2011.11.002

  65. Pavlica S, Piscioneri A, Peinemann F, Keller M, Milosevic J, Staeudte A, Heilmann A, Schulz-Siegmund M, Laera S, Favia P, De Bartolo L, Bader A. Rat embryonic liver cell expansion and differentiation on NH3 plasma-grafted PEEK-WC-PU membranes. Biomaterials. 2009;30:6514-6521. doi: 10.1016/j.biomaterials.2009.08.024

  66. De la RB, Nowak C, Sanchez E, Hernandez A, Schulz-Siegmund M, Pec MK, Delgado A, Evora C. VEGF-controlled release within a bone defect from alginate/chitosan/PLA-H scaffolds. Eur J Pharm Biopharm. 2009;73:50-58. doi: 10.1016/j.ejpb.2009.04.014

  67. Nemec K, Germ E, Schulz-Siegmund M, Ortner A. The effect of nimodipine, fentanyl and remifentanil intravenous products on the stability of propofol emulsions. Pharmazie. 2009;64:94-97. doi: 10.1691/ph.2008.8161

  68. Lorenz K, Sicker M, Schmelzer E, Rupf T, Salvetter J. Schulz-Siegmund M, Bader A. Multilineage Differentiation Potential of Human Dermal Skin Derived Fibroblasts, Exp Dermatol. 2008;17:925-932. doi: 10.1111/j.1600-0625.2008.00724.x

  69. Hacker M, Ringhofer M, Neubauer M, Vogel T, Appel B, Young S, Mikos AG, Blunk T, Göpferich A, Schulz MB. Solid Lipid Templating: Solid lipid Templating of macroporous tissue engineering scaffolds, Biomaterials. 2007;28:3497-3507. doi: 10.1016/j.biomaterials.2007.04.018

  70. Ahmed N, Vogel B, Rohde E, Strunk D, Grifka J, Schulz MB, Grassel S. CD45-positive cells of haematopoietic origin enhance chondrogenic marker gene expression in rat marrow stromal cells, Int.J Mol.Med. 2006;18:233-240.

  71. Neubauer M, Hacker M, Bauer-Kreisel P, Weiser B, Fischbach C, Schulz MB, Goepferich A, Blunk T. Adipose Tissue Engineering Based on Mesenchymal Stem Cells and Basic Fibroblast Growth Factor in vitro. Tissue Eng. 2005;11(11/12):1840-1851. doi: 10.1089/ten.2005.11.1840

  72. Lieb E, Vogel T, Milz S, Dauner M, Schulz MB. Effects of transforming growth factor beta1 on bonelike tissue formation in three-dimensional cell culture. II: Osteoblastic differentiation. Tissue Eng. 2004;10:1414-1425. doi: 10.1089/ten.2004.10.1414

  73. Lieb E, Milz S, Vogel T, Hacker M, Dauner M, Schulz MB. Effects of transforming growth factor beta1 on bonelike tissue formation in three-dimensional cell culture. I. Culture conditions and tissue formation. Tissue Eng. 2004;10:1399-1413. doi: 10.1089/ten.2004.10.1399

  74. Lieb E, Hacker M, Tessmar J, Kunz-Schughart LA, Fiedler J, Dahmen C, Hersel U, Kessler H, Schulz MB, Gopferich A. Mediating specific cell adhesion to low-adhesive diblock copolymers by instant modification with cyclic RGD peptides. Biomaterials. 2005;26:2333-2341. doi: 10.1016/j.biomaterials.2004.07.010

  75. Neubauer M, Fischbach C, Bauer-Kreisel P, Lieb E, Hacker M, Tessmar J, Schulz MB, Goepferich A, Blunk T. Basic fibroblast growth factor enhances PPARgamma ligand-induced adipogenesis of mesenchymal stem cells. FEBS Lett. 2004;577:277-283. doi: 10.1016/j.febslet.2004.10.020

  76. Tessmar J, Kellner K, Schulz MB, Blunk T, Gopferich A. Toward the Development of Biomimetic Polymers by Protein Immobilization: PEGylation of Insulin as a Model Reaction. Tissue Eng. 2004;10: 441-453. doi: 10.1089/107632704323061807

  77. Kellner K, Tessmar J, Milz S, Angele P, Nerlich M, Schulz MB, Blunk T, Gopferich A. PEGylation Does Not Impair Insulin Efficacy in Three-Dimensional Cartilage Culture: An Investigation toward Biomimetic Polymers. Tissue Eng. 2004;10:429-440. doi: 10.1089/107632704323061799

  78. Hacker M, Tessmar J, Neubauer M, Blaimer A, Blunk T, Göpferich A, Schulz MB. Towards biomimetic scaffolds - Anhydrous scaffold fabrication from biodegradable amine reactive diblock copolymers, Biomaterials. 2003;24(24):4459-4473. doi: 10.1016/S0142-9612(03)00346-6

  79. Lieb E, Tessmar J, Hacker M, Fischbach C, Rose D, Blunk T, Mikos AG, Goepferich A, Schulz MB. Poly(D,L-lactic acid)-poly(ethylene glycol)-monomethyl ether Diblock Copolymers Control Adhesion and Osteoblastic Differentiation of Marrow Stromal Cells, Tissue Eng. 2003;9(1):69-82. doi: 10.1089/107632703762687555

  80. Kellner K, Liebsch G, Klimant I, Wolfbeis OS, Blunk T, Schulz MB, Gopferich A. Determination of oxygen gradients in engineered tissue using a fluorescent sensor, Biotechnol. Bioeng. 2002;80:73-83. doi: 10.1002/bit.10352

  81. Kellner K, Lang K, Papadimitriou A, Leser U, Milz S, Schulz MB, Blunk T, Gopferich A. Effects of hedgehog proteins on tissue engineering of cartilage in vitro, Tissue Eng. 2002;8:561-572. doi: 10.1089/107632702760240481

  82. Kellner K, Schulz MB, Gopferich A, Blunk T. Insulin in tissue engineering of cartilage: a potential model system for growth factor application, J. Drug Target. 2001;9:439-448. doi: 10.3109/10611860108998778

  83. Schulz M, Daniels R. Hydroxypropylmethylcellulose (HPMC) as emulsifier for submicron emulsions - Influence of molecular weight and substitution type on the droplet size after high pressure homogenisation, Eur. J. Pharm. Biopharm. 2000;49:231-236. doi: 10.1016/S0939-6411(00)00069-2

​​Weitere Publikationen und Buchkapitel​​

  1. Sedaghati B, Hoyer J, Aigner A, Hacker MC, Schulz-Siegmund M. Controlled Release Technologies for RNAi Strategies in Regenerative Medicine In: Gustav Steinhoff (Ed): Regenerative Medicine - from Protocol to Patient. 2016.

  2. Flath T, Hacker M, Schulz-Siegmund M, Schulze P. Bioaktive Implantate im FDM-Verfahren. In: 3-D & Industrie, Mitteldeutsche Forum Rapid Technologien, DESOTRON. 2014.

  3. Schulz-Siegmund M, Hötzel R, Hoffmeister PG, Hacker MC. Synthesis, Processing and Characterization of Ceramic Biomaterials for Biomedical Applications, Chapter 3. In: Balaji Sitharaman (Ed), Nanobiomaterials Handbook, CRC Press. 2011.

  4. Hacker M, Ambrosch K, Schulz-Siegmund M. Macroporous Polymer Scaffolds Through Leaching Processes. In: Macroporous Polymers: Production, Properties and Biotechnological/Biomedical Application Ashok Kumar, Igor Yu Galeaev (Eds). CRC Press. 2009.

  5. Schuessele A, Volk B, Mayr H, Blunk T, Schulz MB, Goepferich A. Surface modification of hydroxyapatite ceramics to modulate cell adhesion and improve tissue generation, In: Proceedings of the 9th conference on ceramics, cells and tissues: chemistry and microstructure, the. Ed. Ravaglioli A, Krajewski A, Forli. 2005.

  6. Schulz M, Blunk T, Göpferich A. Lebende Gewebe aus dem Reagenzglas - Wie sich Knochen, Knorpel und andere Gewebe in vitro erzeugen lassen, Blick in die Wissenschaft. 1999.

  7. Schulz M, Blunk T, Göpferich A. Bioabbaubare Polymere: Tür zu Arzneiformen und künstlichen lebenden Geweben, Pharmazeutische Zeitung. 1999.

  8. Blunk T, Schulz M, Göpferich A. Herstellung künstlicher Gewebe unter Einsatz von Biopolymeren und Applikationsformen zur kontrollierten Freigabe. In: Kayser O, Müller RH (Eds.), Pharmazeutische Biotechnologie, Wissenschaftliche Verlagsgesellschaft. 2000.​


  1. Deutsche Patentanmeldung Nr. 10 2014 224 654.7 „Makroporöse, bioabbaubare organisch-vernetzte Silikat-Hybridmaterialien zur Implantation" (angemeldet).

  2. Savkovic V, Dieckmann C, Simon JC, Schulz-Siegmund M, Hacker M. Method for deriving melanocytes from the hair follicle outer root sheath and preparation for grafting WO2013060899 A3 (Juni 20, 2013).

  3. Göpferich A, Tessmar J, Schulz M, Blunk T, Mikos A. Biodegradable Block Copolymers with Modifiable Surface. WO 20070299227 (Dezember 27, 2007).

  4. Lauer K, Lang K, Papadimitriou A, Reiff U, Schulz M, Blunk T, Goepferich A. Methods and Reagents for Tissue Engineering in vitro, WO 20060246041, (November 2, 2006).​​
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