Beller P, Fink P, Wolf F, Männle D, Helmle I, Kuttenlochner W, Unterfrauner D, Engelbrecht A, Staudt ND, Kulik A, Groll M, Gross H, Kaysser L* "Characterization of the cystargolide biosynthetic gene cluster and functional analysis of the methyltransferase CysG." J Biol Chem 2023; 300(1): 105507. ISSN 0021-9258. DOI: 10.1016/j.jbc.2023.105507.​ (*senior authorship)

Illigmann A, Vielberg MT, Lakemeyer M, Wolf F, Dema T, Stange P, Kuttenlochner W, Liebhart E, Kulik A, Staudt ND, Malik I, Grond S, Sieber SA, Kaysser L*, Groll M*, Brötz-Oesterhelt H* "Structure of Staphylococcus aureus ClpP Bound to the Covalent Active-Site Inhibitor Cystargolide A." Angew Chem Int Ed Engl 2023; Epub: e202314028. ISSN 1433-7851. DOI: 10.1002/anie.202314028. (*senior authorship)

A. Engelbrecht, F. Wolf, A. Esch, A. Kulik, S. I. Kozhushkov, A. de Meijere, C. C. Hughes*, and L. Kaysser* "Discovery of a Cryptic Nitro Intermediate in the Biosynthesis of the 3-(trans-2′-Aminocyclopropyl)alanine Moiety of Belactosin A." Organic Letters (2022), (*corresponding author)

S. Shimo, R. Ushimaru*, A. Engelbrecht, M. Harada, K. Miyamoto, A. Kulik, M. Uchiyama, L. Kaysser*, I. Abe* "Stereodivergent Nitrocyclopropane Formation during Biosynthesis of Belactosins and Hormaomycins." Journal of the American Chemical Society (2021), 143(44):18413-18418. (*corresponding author)

A. Engelbrecht, H. Saad, H. Gross, L. Kaysser* "Natural Products from Nocardia and Their Role in Pathogenicity" Microbial Physiology (2021), 31(3):217–232

M.A Schorn, S. Verhoeven, L. Ridder, F. Huber, …, L. Kaysser, …, D. Männle, …, K.R Duncan, M. Crüsemann, S. Rogers, P.C. Dorrestein, M.H Medema, J. van der Hooft "A community resource for paired genomic and metabolomic data mining" Nature Chemical Biology (2021), 17(4):363-368

P. Marquardt, R. Seide, C. Vissiennon, A. Schubert, C. Birkemeyer, V. Ahyi and K. Fester "Phytochemical characterization and in vitro anti-inflammatory, antioxidant and antimicrobial activity of combretum collinum fresen leaves extracts from Benin" Molecules (2020), 25(2):288

P. Marquardt, C. Vissiennon, A. Schubert, C. Birkemeyer, V. Ahyi and K. Fester "Phytochemical Analysis, In Vitro Anti-Inflammatory and Antimicrobial Activity of Piliostigma thonningii Leaf Extracts from Benin." Planta Medica (2020), 86(17):1269-1277

P. Marquardt, C. Vissiennon, V. Ahyi, and K. Fester."Von der traditionellen Anwendung zur rationalen Phytotherapie: Phytochemische Analyse und prä-klinische Untersuchungen zur antimikrobiellen Wirkung von Blätterextrakten von Combretum collinum Fresen" Zeitschrift für Phytotherapie (2020), 41(04):170-176

D. Männle, S. McKinnie, Z. Lu, B.S. Moore, N. Ziemert* and L. Kaysser* "Comparative genomics to metabolomics in the genus Nocardia." mSystems (2020), 5(3):e00125-20. (*corresponding author)

J. Chen, A. Frediansyah, D. Männle, J. Straetener, H. Brötz-Oesterhelt, N. Ziemert, L. Kaysser, H. Gross "New Nocobactin Derivatives with Antimuscarinic Activity, Terpenibactins A-C, Revealed by Genome Mining of Nocardia terpenica IFM 0406." Chembiochem (2020), 21(15):2205-2213.

F. Wiker, M. Konnerth, I. Helmle, A. Kulik, L. Kaysser, H. Gross and B. Gust "Identification of novel α-pyrones from Conexibacter woesei serving as sulfate shuttles." ACS Chemical Biology  (2019), 14(9):1972-1980

​​​L. Kaysser* "Build to bind: biosynthetic strategies for the formation of small-molecule protease inhibitors." Natural Product Reports (2019), 36(12):1654-1686 (*corresponding author)

A. Baulig, I. Helmle, M. Bader, F. Wolf, A. Kulik, H. Gross and L. Kaysser* "Biosynthetic reconstitution of deoxysugar phosphoramidate metalloprotease inhibitors using an N-P-bond-forming kinase." Chemical Science (2019), 10:4486 (*corresponding author)

F. Wolf, F. Leipoldt, A. Kulik and L. Kaysser* "Characterization of the actinonin biosynthetic gene cluster." ChemBioChem (2018), 19(11):1189-1195. (*corresponding author)

F. Leipoldt, J. Santos-Aberturas, D.P. Stegmann, F. Wolf, A. Kulik, R. Lacret, D. Popadić, D. Keinhörster, N. Kirchner, P. Bekiesch, H. Gross, A.W. Truman* and L. Kaysser* "Warhead biosynthesis and the origin of structural diversity in hydroxamate metalloproteinase inhibitors." Nature Communications (2017), 8(1):1965. (*corresponding author)

F. Wolf, J.S. Bauer, T.M. Bendel, A. Kulik, J. Kalinowski, H. Gross and L. Kaysser* "Biosynthesis of the β-lactone proteasome inhibitors belactosins and cystargolides." Angewandte Chemie Internationale Edition (2017), 56(23):6665-6668. (*corresponding author)

L. Kaysser* "Genom-basierte Suche nach Protease-Inhibitoren aus bakteriellen Quellen." Biospektrum (2017), 23(1):41-45 (*corresponding author)

J. Zettler, F. Zubeil, A. Kulik, S. Grond and L. Kaysser* "Epoxomicin and Eponemycin Biosynthesis Involves gem-Dimethylation and an AcylCoA Dehydrogenase-like Enzyme." ChemBioChem (2016), 17(9):792-8. (*corresponding author)

F. Leipoldt, P. Zeyhle, A. Kulik, J. Kalinowski, L. Heide and L. Kaysser* "Diversity of ABBA prenyltransferases in Streptomyces sp. CNQ-509: Promiscuous enzymes for the biosynthesis of meroterpenoid compounds." PLoS ONE (2015), 10(12):e0143237 (*corresponding author)

M.H. Medema, R. Kottmann, P. Yilmaz, M. Cummings, .., L. Kaysser, .., F.O. Glöckner "Minimum Information about a Biosynthetic Gene cluster" Nature Chemical Biology (2015), 11(9):625–631.

C. Rückert, F. Leipoldt, P. Zeyhle, W. Fenical, P.R. Jensen, J. Kalinowski, L. Heide and L. Kaysser* "Complete Genome Sequence of Streptomyces sp. CNQ-509, a Prolific Producer of Meroterpenoid Chemistry." Journal of Biotechnology (2015), 216:140-1 (*corresponding author)

M. Schorn, J. Zettler, J.P. Noel, P. Dorrestein, B.S. Moore* and L. Kaysser* "The genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors." ACS Chemical Biology (2014), 9(1):301-309. (*corresponding author)

L. Kaysser* "Resistent: Wie Antibiotika wirken und wie Bakterien sie wirkungslos machen" Deutsche Apotheker Zeitung (2014), 154(5):368-74. (*corresponding author)

R. Teufel, L. Kaysser, M.T. Villaume, S. Diethelm, M.K. Carbullido, P.S. Baran and B.S. Moore "One-pot Enzymatic Synthesis of Merochlorins A and B." Angewandte Chemie Internationale Edition (2014), 53(41):11019-22.

S. Diethelm, R. Teufel, L. Kaysser and B.S. Moore "A Multitasking Vanadium-Dependent Chloroperoxidase as an Inspiration for the Chemical Synthesis of the Merochlorins." Angewandte Chemie Internationale Edition (2014), 53(41):11023-26.

X. Tang, K. Eitel, L. Kaysser, A. Kulik, S. Grond and B. Gust "A two-step sulfation mechanism in antibiotic biosynthesis requires a type III polyketide synthase." Nature Chemical Biology (2013), 9(10):610-15.

L. Kaysser, P. Bernhardt, S.-J. Nam, S. Loesgen, J.G. Ruby, P. Skewes-Cox, P.R. Jensen, W. Fenical and B.S. Moore "Merochlorins A−D, Cyclic Meroterpenoid Antibiotics Biosynthesized in Divergent Pathways with Vanadium-Dependent Chloroperoxidases." Journal of the American Chemical Society (2012), 134(29):11988-91.

L. Kaysser, X. Tang, E. Wemakor, K. Sedding, S. Hennig, S. Siebenberg and B. Gust "Identification of the Napsamycin Gene Cluster by Genome Mining." ChemBioChem (2011), 12(3):477-87.

S. Siebenberg, L. Kaysser, E. Wemakor, L. Heide, B. Gust and B. Kammerer "Identification and structural elucidation of new Caprazamycins from Streptomyces sp. MK730-62F2 by liquid chromatography/electrospray ionization tandem mass spectrometry." Rapid Communications in Mass Spectrometry (2011), 25:495-502.

K. Flinspach, L. Westrich, L. Kaysser, S. Siebenberg, J.P. Gomez-Escribano, M. Bibb B. Gust, and L. Heide "Heterologous expression of the biosynthetic gene clusters of coumermycin A1, clorobiocin and caprazamycins in genetically modified Streptomyces coelicolor strains." Biopolymers (2010), 93(9):823-32

L. Kaysser, E. Wemakor, S. Siebenberg, J. Salas, J.K. Sohng, B. Kammerer and B. Gust "Caprazamycin Biosynthesis: Formation and Attachment of the Deoxysugar Moiety and Assembly of the Gene Cluster." Applied and Environmental Microbiology (2010), 76(12):4008-18.

L. Kaysser, K. Eitel, T. Tanino, S. Siebenberg, A. Matsuda, S. Ichikawa, and B. Gust "A New ASST-type Sulfotransferase Involved in Liponucleoside Antibiotic Biosynthesis in Streptomycetes." Journal of Biological Chemistry (2010), 285(17):12684-94.

L. Kaysser, S. Siebenberg, B. Kammerer and B. Gust "Analysis of the Liposidomycin Gene Cluster Leads to the Identification of New Caprazamycin Derivatives." ChemBioChem (2010), 11(2):191-96.

L. Kaysser, L. Lutsch, S. Siebenberg, E. Wemakor, B. Kammerer and B. Gust "Identification and Manipulation of the Caprazamycin Gene Cluster Leads to New Simplified Liponucleoside Antibiotics and Gives Insights into the Biosynthetic Pathway." Journal of Biological Chemistry (2009), 284(22):14987-96.

X. Zhao, L. Kaysser "Meeting report: the 13th International Biotechnology Symposium and Exhibition in Dalian, China." Biotechnology Journal (2009), 4(1):23-27.

J.B. van Beilen, E.G. Funhoff, A. van Loon, A. Just, L. Kaysser, M. Bouza, R. Holtackers, M. Röthlisberger, Z. Li, B. Witholt, "Cytochrome P450 alkane hydroxylases of the CYP153 family are common in alkane-degrading eubacteria lacking integral membrane alkane hydroxylases." Applied and Environmental Microbiology (2006), 72(1):59-65.

S. Eiben, L. Kaysser, S. Maurer, K. Kühnel, V.B. Urlacher, R.D. Schmid "Preparative use of isolated CYP102 monooxygenases - a critical appraisal." Journal of Biotechnology (2006), 124(4):662-69.

S. Maurer, K. Kühnel, L. Kaysser, S. Eiben, R.D. Schmid and V.B. Urlacher "Catalytic Hydroxylation in Biphasic Systems using CYP102A1 (P450 BM-3) Mutants." Advanced Synthesis and Catalysis (2005), 347:1090-98.

​Patent Applications 

B. Gust, L. Kaysser, K. Eitel „Die Sulfotransferase Cpz4, ein Biokatalysator zur Herstellung sulfatisierter Liponukleosid-Antibiotika". DE 10 2010 005 273.6, Deutsches Patent- und Markenamt (2010).

B. Gust, L. Kaysser „Ein neues Caprazamycin Biosynthesegencluster". DE 10 2009 014 432.3, Deutsches Patent- und Markenamt (2009).


Brüderstraße 34, EG
04103 Leipzig
Pharmazeutische Chemie:
0341 97 - 11800
Pharmazeutische Biologie:
0341 97 - 11900
0341 97 - 11813