Pohl F*, Seufert F*, Chung YK (鍾炫坤), Schick R, Kieslich B, Schöneberg T, Langenhan T#, Hildebrand PW#, Sträter N# (2026). Structural basis of GAIN domain autoproteolysis and cleavage-resistance in the adhesion G-protein coupled receptors. Nat. Commun., 17, 3259.
DOI: 10.1038/s41467-026-71225-1
Bormann A*, Körner MB*, Dahse AK*, Gläser MS, Irmer J, Lede V, Alenfelder J, Lehmann J, Hall DCN, Thane M, Schleyer M, Kostenis E, Schöneberg T, Bigl M, Langenhan T, Ljaschenko D#, Scholz N# (2025). Intron retention of an adhesion GPCR generates 1TM isoforms required for 7TM-GPCR function. Cell Rep., 44(1),115078.
DOI: 10.1016/j.celrep.2024.115078
DOI: 10.1038/s41467-024-55466-6
Körner MB#, Velluva A, Bundalian L, Krohn K, Schön K, Schumann I, Kromp J, Thum AS, Garten A, Hentschel J, Jamra RA, Mrestani A, Scholz N, Langenhan T, Le Duc D# (2025). Drosophila WDFY3/Bchs overexpression impairs neural function. J. Neurogenet., 1-16.
DOI: 10.1080/01677063.2025.2465536
Langenhan T (2024). Modularization of adhesion G protein-coupled receptor (aGPCR) structure: how alternative splicing regulates synaptogenesis. Signal Transduct. Target. Ther., 9, 106.
DOI: 10.1038/s41392-024-01829-w
Buhlan M, Ljaschenko D, Scholz N#, Langenhan T# (2024). Experimental modulation of physiological force application on leg joint neurons in intact Drosophila melanogaster. Nat. Protoc., 19, 113-126.
DOI: 10.1038/s41596-023-00907-7
Vieira Contreras F*, Auger GM*, Müller L, Richter V, Huetteroth W, Seufert F, Hildebrand PW, Scholz N, Thum AS, Ljaschenko D, Blanco-Redondo B#, Langenhan T# (2024). The adhesion G-protein-coupled receptor mayo/CG11318 controls midgut development in Drosophila. Cell Rep., 43, 113640.
DOI: 10.1016/j.celrep.2023.113640
Strutt H#, Warrington S, Madathil ACK, Langenhan T, Strutt D# (2023). Molecular symmetry breaking in the Frizzled-dependent planar polarity pathway. Curr. Biol., 33(24), 5340-5354.
DOI: 10.1016/j.cub.2023.10.071
Streit M*, Hemberger M*, Häfner S*, Knote F, Langenhan T#, Beliu G# (2023). Optimized genetic code expansion technology for time-dependent induction of adhesion GPCR-ligand engagement. Protein Sci., 32, 4614.
DOI: 10.1002/pro.4614
Seufert F*, Chung YK*, Hildebrand PW#, Langenhan T# (2023). 7TM domain structures of adhesion GPCRs: what’s new and what’s missing? Trends Biochem. Sci., 48(8), 726-739.
DOI: 10.1016/j.tibs.2023.05.007
Alexander SPH & CGTP Collaborators (2023). The concise guide to pharmacology 2023/24: G protein-coupled receptors. Br. J. Pharmacol., 180 Suppl 2, S23-S144.
DOI: 10.1111/bph.16177
Mrestani A*, Dannhäuser S*, Pauli M, Kollmannsberger P, Hübsch M, Morris L, Langenhan T, Heckmann M#, Paul MM# (2023). Nanoscaled RIM clustering at presynaptic active zones revealed by endogenous tagging. Life Sci. Alliance, 6(12), e202302021.
DOI: 10.26508/lsa.202302021
Langenhan T (2023). Adhesion GPCRs in glioblastoma revisited. Cell Rep., 42(1), 113474.
DOI: 10.1016/j.celrep.2023.113474
Fu C, Huang W, Tang Q, Niu M, Guo S, Langenhan T, Song G#, Yan J# (2023). Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs. Nano Lett., 23(20), 9179-9186.
DOI: 10.1021/acs.nanolett.3c01163
Scholz N*#, Dahse AK*, Kemkemer M, Bormann A, Auger GM, Vieira Contreras F, Ernst LF, Staake H, Körner MB, Buhlan M, Meyer-Mölck A, Chung YK, Blanco-Redondo B, Klose F, Jarboui MA, Ljaschenko D, Bigl M, Langenhan T# (2023). Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation. Nature, 615(7954), 945-953.
DOI: 10.1038/s41586-023-05802-5
Körner MB*, Velluva A*, Bundalian L, Radtke M, Lin CC, Zacher P, Bartolomaeus T, Kirstein AS, Mrestani A, Scholz N, Platzer K, Teichmann AC, Hentschel J, Langenhan T, Lemke JR, Garten A, Abou Jamra R#, Le Duc D# (2022). Altered gene expression profiles impair the nervous system development in individuals with 15q13.3 microdeletion. Sci. Rep., 12(1), 13507.
DOI: 10.1038/s41598-022-17604-2
Paul MM*, Dannhäuser S*, Morris L*, Mrestani A*, Hübsch M, Gehring J, Hatzopoulos GN, Pauli M, Auger GM, Bornschein G, Scholz N, Ljaschenko D, Müller M, Sauer M, Schmidt H, Kittel RJ, DiAntonio A, Vakonakis I, Heckmann M#, Langenhan T# (2022). The human cognition-enhancing CORD7 mutation increases active zone number and synaptic release. Brain, 145, 3787–3802.
DOI: 10.1093/brain/awac011
Götze KJ*, Mrestani A*, Beckmann P, Krohn K, Duc DL, Velluva A, Böhme MA, Heckmann M, Jamra RA, Lemke JR, Bläker H, Scholz N, Ljaschenko D#, Langenhan T# (2022). Improving one-step scarless genome editing in Drosophila melanogaster by combining ovoD co-CRISPR selection with sgRNA target site masking. Biol. Methods Protoc., 7, bpac003.
DOI: 10.1093/biomethods/bpac003
Beliu G*, Altrichter S*, Guixà-González R*, Hemberger M, Brauer I, Dahse A-K, Scholz N, Wieduwild R, Kuhlemann A, Batebi H, Seufert F, Pérez-Hernández G, Hildebrand PW#, Sauer M#, Langenhan T# (2021). Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain. Mol. Cell, 81, 905-921.e5.
DOI: 10.1016/j.molcel.2020.12.042
Buettner JM*, Longang JKS*, Gerstner F, Apel KS, Blanco-Redondo B, Sowoidnich L, Janzen E, Langenhan T, Wirth B, Simon CM# (2021). Central synaptopathy is the most conserved feature of motor circuit pathology across SMA mouse models. iScience,103376.
DOI: 10.1016/j.isci.2021.103376
Dannhäuser S*, Lux TJ*, Hu C, Selcho M, Chen JT-C, Ehmann N, Sachidanandan D, Stopp S, Pauls D, Pawlak M, Langenhan T, Soba P, Rittner HL#, Kittel RJ# (2020). Antinociceptive modulation by the adhesion GPCR CIRL promotes mechanosensory signal discrimination. eLife, 9, e56738.
DOI: 10.7554/eLife.56738
Mathiasen S, Palmisano T, Perry NA, Stoveken HM, Vizurraga A, McEwen DP, Okashah N, Langenhan T, Inoue A, Lambert NA, Tall GG, Javitch JA# (2020). G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3. Nat. Chem. Biol., 16, 1343–1350.
DOI: 10.1038/s41589-020-0617-7
Scholz N, Langenhan T#, Schöneberg T# (2019). Revisiting the classification of adhesion GPCRs. Ann. N. Y. Acad. Sci., 1456, 80–95.
DOI: 10.1111/nyas.14192
Blanco-Redondo B#, Nuwal N, Kneitz S, Nuwal T, Halder P, Liu Y, Ehmann N, Scholz N, Mayer A, Kleber J, Kähne T, Schmitt D, Sadanandappa MK, Funk N, Albertova V, Helfrich-Förster C, Ramaswami M, Hasan G, Kittel RJ, Langenhan T, Gerber B, Buchner E# (2019). Implications of the Sap47 null mutation for synapsin phosphorylation, longevity, climbing proficiency and behavioural plasticity in adult Drosophila. J. Exp. Biol., 222, jeb203505.
DOI: 10.1242/jeb.203505
Langenhan T (2019). Adhesion G protein–coupled receptors—Candidate metabotropic mechanosensors and novel drug targets. Basic Clin. Pharmacol. Toxicol., 126, 5–16.
DOI: 10.1111/bcpt.13223
Scholz N*, Ehmann N*, Sachidanandan D, Imig C, Cooper BH, Jahn O, Reim K, Brose N, Meyer J, Lamberty M, Altrichter S, Bormann A, Hallermann S, Pauli M, Heckmann M, Stigloher C, Langenhan T#, Kittel RJ# (2019). Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix. J. Cell Biol., 218, 1011–1026.
DOI: 10.1083/jcb.201806155
Blanco-Redondo B, Langenhan T# (2018). Parallel Genomic Engineering of Two Drosophila Genes Using Orthogonal attB/attP Sites. G3: Genes Genomes Genet., 8, g3.200565.2018.
DOI: 10.1534/g3.118.200565
Scholz N*, Guan C*, Nieberler M*, Grotemeyer A*, Maiellaro I, Gao S, Beck S, Pawlak M, Sauer M, Asan E, Rothemund S, Winkler J, Prömel S, Nagel G, Langenhan T#, Kittel RJ# (2017). Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons. eLife, 6, e28360.
DOI: 10.7554/eLife.28360
Scholz N#, Monk KR, Kittel RJ, Langenhan T# (2016). Adhesion GPCRs as a Putative Class of Metabotropic Mechanosensors. Handb. Exp. Pharmacol., 234, 221–247.
DOI: 10.1007/978-3-319-41523-9_10
Backhaus P, Langenhan T, Neuser K# (2016). Effects of transgenic expression of botulinum toxins in Drosophila. J. Neurogenet., 30, 22–31.
DOI: 10.3109/01677063.2016.1166223
Nieberler M, Kittel RJ, Petrenko AG, Lin HH#, Langenhan T# (2016). Control of Adhesion GPCR Function Through Proteolytic Processing. Handb. Exp. Pharmacol., 234, 83-109.
DOI: 10.1007/978-3-319-41523-9_5
Langenhan T#, Piao X# Monk KR#(2016). Adhesion G protein-coupled receptors in nervous system development and disease. Nat. Rev. Neurosci., 17(9), 550-61.
DOI: 10.1038/nrn.2016.86
Hamann J*#, Aust G*, Araç D, Engel FB, Formstone C, Fredriksson R, Hall RA, Harty BL, Kirchhoff C, Knapp B, Krishnan A, Liebscher I, Lin HH, Martinelli DC, Monk KR, Peeters MC, Piao X, Prömel S, Schöneberg T, Schwartz TW, Singer K, Stacey M, Ushkaryov YA, Vallon M, Wolfrum U, Wright MW, Xu L, Langenhan T*, Schiöth HB*# (2015). International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors. Pharmacol. Rev., 67, 338–367.
DOI: 10.1124/pr.114.009647
Scholz N*, Gehring J*, Guan C*, Ljaschenko D, Fischer R, Lakshmanan V, Kittel RJ#, Langenhan T# (2015). The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation. Cell Rep., 11, 866–874.
DOI: 10.1016/j.celrep.2015.04.008
Monk K, Hamann J, Langenhan T, Nijmeijer S, Schöneberg T, Liebscher I# (2015). Adhesion GPCRs: From in vitro pharmacology to in vivo mechanisms. Mol. Pharmacol., 88(3), 617-23.
DOI: 10.1124/mol.115.098749
Langenhan T#, Barr MM, Bruchas MR, Ewer J, Griffith LC, Maiellaro I, Taghert PH, White BH, Monk KR# (2015). Model organisms in G protein–coupled receptor research. Mol. Pharmacol., 88(3), 596-603.
DOI: 10.1124/mol.115.098764
Liebscher I, Ackley B, Arac D, Ariestanti DM, Aust G, Bae B-I, Bista BR, Bridges JP, Duman JG, Engel FB, Giera S, Goffinet AM, Hall RA, Hamann J, Hartmann N, Lin, H-H, Liu M, Luo R, Mogha A, Monk KR, Peeters MC, Prömel S, Ressl S, Schiöth HB, Sigoillot SM, Song H, Talbot WS, Tall GG, White JP, Wolfrum U, Xu L, Piao X# (2014). New functions and signaling mechanisms for the class of adhesion G protein–coupled receptors. Ann. N. Y. Acad. Sci., 1333(1), 43-64.
DOI: 10.1111/nyas.12580
Dawydow A*, Gueta R*, Ljaschenko D, Ullrich S, Hermann M, Ehmann N, Gao S, Fiala A, Langenhan T, Nagel G#, Kittel RJ# (2014). Channelrhodopsin-2-XXL, a powerful optogenetic tool for low-light applications. Proc. Natl. Acad. Sci. U.S.A., 111, 13972–13977.
DOI: 10.1073/pnas.1408269111
Langenhan T*#, Aust G*, Hamann J* (2013). Sticky Signaling – Adhesion Class G Protein–Coupled Receptors Take the Stage. Sci. Signal., 6(276), re3.
DOI: 10.1126/scisignal.2003825
Prömel S, Langenhan T#, Araç D# (2013). Matching structure with function: the GAIN domain of Adhesion-GPCR and PKD1-like proteins. Trends Pharmacol. Sci., 34, 470–478.
DOI: 10.1016/j.tips.2013.06.002
Prömel S, Aust G, Langenhan T, Schöneberg T# (2013). Adhäsions-G-Protein-gekoppelte Rezeptoren – rätselhafte Riesen. Biospektrum, 19(7), 717-719.
DOI: 10.1007/s12268-013-0379-9
Prömel S#, Waller‐Evans H, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MBL, Grosse J, Schöneberg T, Russ AP, Langenhan T# (2012). Characterization and functional study of a cluster of four highly conserved orphan adhesion‐GPCR in mouse. Dev. Dyn., 241, 1591–1602.
DOI: 10.1002/dvdy.23841
Prömel S, Frickenhaus M, Hughes S, Mestek L, Staunton D, Woollard A, Vakonakis I, Schöneberg T, Schnabel R, Russ AP*, Langenhan T*# (2012). The GPS Motif Is a Molecular Switch for Bimodal Activities of Adhesion Class G Protein-Coupled Receptors. Cell Rep., 2, 321–331.
DOI: 10.1016/j.celrep.2012.09.012
Araç D, Aust G, Calebiro D, Engel FB, Formstone C, Goffinet A, Hamann J, Kittel RJ, Liebscher I, Lin HH, Monk KR, Petrenko A, Piao X, Prömel S, Schiöth HB, Schwartz TW, Stacey M, Ushkaryov YA, Wobus M, Wolfrum U, Xu L, Langenhan T# (2012). Dissecting signaling and functions of adhesion G protein–coupled receptors. Ann. N. Y. Acad. Sci., 1276(1), 1-25.
DOI: 10.1111/j.1749-6632.2012.06820.x
McGuinness L, Taylor C, Taylor RDT, Yau C, Langenhan T, Hart ML, Christian H, Tynan PW, Donnelly P, Emptage NJ# (2010). Presynaptic NMDARs in the hippocampus facilitate transmitter release at theta frequency. Neuron, 68, 1109–1127.
DOI: 10.1016/j.neuron.2010.11.023
Waller-Evans H, Prömel S, Langenhan T, Dixon J, Zahn D, Colledge WH, Doran J, Carlton MBL, Davies B, Aparicio SAJR, Grosse J, Russ AP# (2010). The Orphan Adhesion-GPCR GPR126 Is Required for Embryonic Development in the Mouse. PLoS One, 5(11), e14047.
DOI: 10.1371/journal.pone.0014047
Langenhan T#, Russ AP# (2010). Latrophilin signalling in tissue polarity and morphogenesis. Adv. Exp. Med. Biol., 706, 37-48.
DOI: 10.1007/978-1-4419-7913-1_3
Langenhan T, Prömel S, Mestek L, Esmaeili B, Waller-Evans H, Hennig C, Kohara Y, Avery L, Vakonakis I, Schnabel R, Russ AP# (2009). Latrophilin signaling links anterior-posterior tissue polarity and oriented cell divisions in the C. elegans embryo. Dev. Cell, 17, 494–504.
DOI: 10.1016/j.devcel.2009.08.008
Vakonakis I#, Langenhan T, Prömel S, Russ A, Campbell ID (2008). Solution structure and sugar-binding mechanism of mouse latrophilin-1 RBL: a 7TM receptor-attached lectin-like domain. Structure, 16(6), 944-953.
DOI: 10.1016/j.str.2008.02.020
Langenhan T (2006). Ciliary neurotrophic factor (CNTF) in the olfactory system of rats and mice. Ann. Anat., 188(5), 411–413.
DOI: 10.1016/j.aanat.2006.05.008
Langenhan T, Sendtner M, Holtmann B, Carroll P, Asan E# (2005). Ciliary neurotrophic factor-immunoreactivity in olfactory sensory neurons. Neuroscience, 134(4), 1179–1194.
DOI: 10.1016/j.neuroscience.2005.05.017
Asan E#, Langenhan T, Holtmann B, Bock H, Sendtner M, Carroll P (2003). Ciliary neurotrophic factor in the olfactory bulb of rats and mice. Neuroscience, 120(1), 99–112.
DOI: 10.1016/S0306-4522(03)00211-2
