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Feja M, Drath I, Weiß S, Ewe A, Gericke B, Outeiro TF, Stefanis L, Aigner A, Richter F. Mol Ther Nucleic Acids. 2025 Aug 6;36(3):102671. doi: 10.1016/j.omtn.2025.102671. eCollection 2025 Sep 9.
RNA drugs and nonviral nanocarriers in oncology – present status and emerging concepts.
Aigner A.
Biochem Biophys Res Commun. 2025 Aug 16;781:152512. doi: 10.1016/j.bbrc.2025.152512. Online ahead of print.
PMID: 40858064
ERBB3 influences the ferroptosis pathway via modulation of lipid peroxidation and GSH synthesis in gastric cancer.
Jenke R, Heinrich T, Lordick F, Aigner A.
Cell Death Discov. 2025 Aug 22;11(1):398. doi: 10.1038/s41420-025-02707-2.
PMID: 40846695
Analysis of Polymer/siRNA Nanoparticle Efficacy and Biocompatibility in 3D Air-Liquid Interface Culture Compared to 2D Cell Culture.
Noske S, Krueger M, Ewe A, Aigner A.
Pharmaceutics. 2025 Mar 6;17(3):339. doi: 10.3390/pharmaceutics17030339.
PMID: 40143003
The MicroRNA miR-454 and the mediator complex component MED12 are regulators of the androgen receptor pathway in prostate cancer.
Guzman J, Hart M, Weigelt K, Neumann A, Aigner A, Andolfi C, Handle F, Rheinheimer S, Fischer U, Immel UD, Lieb V, Meese E, Culig Z, Wullich B, Taubert H, Wach S.
Sci Rep. 2025 Mar 25;15(1):10272. doi: 10.1038/s41598-025-95250-0.
PMID: 40133664
Acquired vulnerability against EGF receptor inhibition in gastric cancer promoted by class I histone deacetylase inhibitor entinostat.
Zenz T, Jenke R, Oliinyk D, Noske S, Thieme R, Kahl T, Gockel I, Meier-Rosar F, Aigner A, Büch TR.
Neoplasia. 2025 Feb;60:101121. doi: 10.1016/j.neo.2024.101121. Epub 2025 Jan 25.
PMID: 39864337
A new human autologous hepatocyte/macrophage co-culture system that mimics drug-induced liver injury-like inflammation.
Zimmermann A, Scheffschick A, Hänsel R, Borchardt H, Liu JL, Ehnert S, Schicht G, Seidemann L, Aigner A, Schiffmann S, Nüssler A, Seehofer D, Damm G.
Arch Toxicol. 2025 Mar;99(3):1167-1185. doi: 10.1007/s00204-024-03943-8. Epub 2024 Dec 22.
PMID: 39710784
The Histone Deacetylase Inhibitor Entinostat Mediates HER2 Downregulation in Gastric Cancer, Providing the Basis for Its Particular Efficacy in HER2-Amplified Tumors and in Combination Therapies.
Zenz T, Jenke R, Thieme R, Kahl T, Borchardt H, Gockel I, Hansen FK, Aigner A, Büch TRH.
Cancer Res Treat. 2025 Jul;57(3):781-802. doi: 10.4143/crt.2024.546. Epub 2024 Dec 10.
PMID: 39668393
Recent advances in development and delivery of non-viral nucleic acid therapeutics for brain tumor therapy.
Kögel D, Temme A, Aigner A.
Pharmacol Ther. 2025 Feb;266:108762. doi: 10.1016/j.pharmthera.2024.108762. Epub 2024 Nov 26.
PMID: 39603349
Pharmacological and pupillary evidence for the noradrenergic contribution to reinforcement learning in Parkinson's disease.
O'Callaghan C, Hezemans FH, Subramaniam N, Ye R, Tsvetanov KA, Murley AG, Holland N, Orlando IF, Regenthal R, Barker RA, Williams-Gray CH, Passamonti L, Robbins TW, Rowe JB.
Commun Biol. 2025 Aug 14;8(1):1223. doi: 10.1038/s42003-025-08627-2.
PMID: 40813904
Natural Compounds and Their Potential in Eating-Related Aspects of Mental Health Disorders.
Ma W, Regenthal R, Krügel U.
Nutrients. 2025 Jul 21;17(14):2383. doi: 10.3390/nu17142383.
PMID: 40733008
Atomoxetine Reduces Decisional Impulsivity in Human Cocaine Addiction.
Lim TV, Cardinal RN, Ziauddeen H, Regenthal R, Sahakian BJ, Robbins TW, Ersche KD.
Biol Psychiatry. 2025 Mar 15;97(6):627-636. doi: 10.1016/j.biopsych.2024.10.018. Epub 2024 Oct 29.
PMID: 39481776
2024
MED12 and CDK8/19 Modulate Androgen Receptor Activity and Enzalutamide Response in Prostate Cancer.
Andolfi C, Bartolini C, Morales E, Gündoğdu B, Puhr M, Guzman J, Wach S, Taubert H, Aigner A, Eder IE, Handle F, Culig Z.
Endocrinology. 2024 Aug 27;165(10):bqae114. doi: 10.1210/endocr/bqae114.
PMID: 39253786
Mesoporous Silica-Based Membranes in Transdermal Drug Delivery: The Role of Drug Loss in the Skin.
Baumann F, Paul T, Ossmann S, Enke D, Aigner A.
Pharmaceutics. 2024 Jul 26;16(8):995. doi: 10.3390/pharmaceutics16080995.
PMID: 39204340
Vorinostat Treatment of Gastric Cancer Cells Leads to ROS-Induced Cell Inhibition and a Complex Pattern of Molecular Alterations in Nrf2-Dependent Genes.
Lorenz L, Zenz T, Oliinyk D, Meier-Rosar F, Jenke R, Aigner A, Büch T.
Pharmaceuticals (Basel). 2024 Aug 16;17(8):1080. doi: 10.3390/ph17081080.
PMID: 39204185
The Concentration of Salivary Extracellular Vesicles Is Related to Obesity.
Röhrborn K, Krueger M, Kalusa M, Fietz SA, Ewe A, Aigner A, Stumvoll M, Kovacs P, Blüher M, Schamarek I, Rohde-Zimmermann K.
Nutrients. 2024 Aug 9;16(16):2633. doi: 10.3390/nu16162633.
PMID: 39203770
Glucose-oxygen deprivation constrains HMGCR function and Rac1 prenylation and activates the NLRP3 inflammasome in human monocytes.
Raulien N, Friedrich K, Strobel S, Raps S, Hecker F, Pierer M, Schilling E, Lainka E, Kallinich T, Baumann S, Fritz-Wallace K, Rolle-Kampczyk U, von Bergen M, Aigner A, Ewe A, Schett G, Cross M, Rossol M, Wagner U.
Sci Signal. 2024 Jul 16;17(845):eadd8913. doi: 10.1126/scisignal.add8913. Epub 2024 Jul 16.
PMID: 39012939
HDAC inhibitors activate lipid peroxidation and ferroptosis in gastric cancer.
Jenke R, Oliinyk D, Zenz T, Körfer J, Schäker-Hübner L, Hansen FK, Lordick F, Meier-Rosar F, Aigner A, Büch T.
Biochem Pharmacol. 2024 Jul;225:116257. doi: 10.1016/j.bcp.2024.116257. Epub 2024 May 4.
PMID: 38705532
Spray-drying of PEI-/PPI-based nanoparticles for DNA or siRNA delivery.
Noske S, Karimov M, Krüger M, Lilli B, Ewe A, Aigner A.
Eur J Pharm Biopharm. 2024 Jun;199:114297. doi: 10.1016/j.ejpb.2024.114297. Epub 2024 Apr 18.
PMID: 38641228
Efficient polymeric nanoparticles for RNAi in macrophage reveal complex effects on polarization markers upon knockdown of STAT3/STAT6.
Walther M, Jenke R, Aigner A, Ewe A.
Eur J Pharm Biopharm. 2024 Apr;197:114232. doi: 10.1016/j.ejpb.2024.114232. Epub 2024 Feb 22.
PMID: 38395176
2023
The effect of novel tyrosine-modified polyethyleneimines on human albumin structure – Thermodynamic and spectroscopic study.
Kubczak M, Grodzicka M, Michlewska S, Karimov M, Ewe A, Aigner A, Bryszewska M, Ionov M.
Colloids Surf B Biointerfaces. 2023 Jul;227:113359. doi: 10.1016/j.colsurfb.2023.113359. Epub 2023 May 16.
PMID: 37209597
Antibody-Drug Conjugates as a Targeted Therapeutic Approach Across Entities in Oncology.
Lordick F, Merz M, Büch E, Aigner A.
Dtsch Arztebl Int. 2023 May 12;120(19):329-336. doi: 10.3238/arztebl.m2023.0093.
PMID: 37073718
Individual hematotoxicity prediction of further chemotherapy cycles by dynamic mathematical models in patients with gastrointestinal tumors.
Topf V, Kheifetz Y, Daum S, Ballhausen A, Schwarzer A, Trung KV, Stocker G, Aigner A, Lordick F, Scholz M, Knödler M.
J Cancer Res Clin Oncol. 2023 Aug;149(10):6989-6998. doi: 10.1007/s00432-023-04601-9. Epub 2023 Feb 28.
PMID: 36854800
Spectral Computed Tomography-Derived Iodine Content and Tumor Response in the Follow-Up of Neuroendocrine Tumors – A Single-Center Experience.
Lim W, Sodemann EB, Büttner L, Jonczyk M, Lüdemann WM, Kahn J, Geisel D, Jann H, Aigner A, Böning G.
Curr Oncol. 2023 Jan 23;30(2):1502-1515. doi: 10.3390/curroncol30020115.
PMID: 36826076
Analysis of polymeric nanoparticle properties for siRNA/DNA delivery in a tumor xenograft tissue slice air-liquid interface model.
Karimov M, Scherer M, Franke H, Ewe A, Aigner A.
Biotechnol J. 2023 Apr;18(4):e2200415. doi: 10.1002/biot.202200415. Epub 2022 Dec 30.
PMID: 36541426
Experimental in vitro, ex vivo and in vivo models in prostate cancer research.
Sailer V, von Amsberg G, Duensing S, Kirfel J, Lieb V, Metzger E, Offermann A, Pantel K, Schuele R, Taubert H, Wach S, Perner S, Werner S, Aigner A.
Nat Rev Urol. 2023 Mar;20(3):158-178. doi: 10.1038/s41585-022-00677-z. Epub 2022 Nov 30.
PMID: 36451039
Pose, duplicate, then elaborate: Steps towards increased affinity for inhibitors targeting the specificity surface of the Pim-1 kinase.
Heyder L, Hochban PMM, Taylor C, Chevillard F, Siefker C, Iking C, Borchardt H, Aigner A, Klebe G, Heine A, Kolb P, Diederich WE.
Eur J Med Chem. 2023 Jan 5;245(Pt 1):114914. doi: 10.1016/j.ejmech.2022.114914. Epub 2022 Nov 9.
PMID: 36410167
The Modulatory Effects of Atomoxetine on Aberrant Connectivity During Attentional Processing in Cocaine Use Disorder.
Nestor LJ, Luijten M, Ziauddeen H, Regenthal R, Sahakian BJ, Robbins TW, Ersche KD.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 Mar;9(3):314-325. doi: 10.1016/j.bpsc.2023.08.003. Epub 2023 Aug 22.
PMID: 37619670
Dimethyl sulfoxide favors the emetic efficacy of lycorine in beagle dogs – a novel strategy for the treatment of poisoning.
Regenthal R, Abraham G.
Res Vet Sci. 2023 Jul;160:11-17. doi: 10.1016/j.rvsc.2023.05.005. Epub 2023 May 17.
PMID: 37210872
Increase in Serotonin Transporter Binding in Patients With Premenstrual Dysphoric Disorder Across the Menstrual Cycle: A Case-Control Longitudinal Neuroreceptor Ligand Positron Emission Tomography Imaging Study.
Sacher J, Zsido RG, Barth C, Zientek F, Rullmann M, Luthardt J, Patt M, Becker GA, Rusjan P, Witte AV, Regenthal R, Koushik A, Kratzsch J, Decker B, Jogschies P, Villringer A, Hesse S, Sabri O.
Biol Psychiatry. 2023 Jun 15;93(12):1081-1088. doi: 10.1016/j.biopsych.2022.12.023. Epub 2023 Jan 18.
PMID: 36997451
2022
Comparison of tyrosine-modified low molecular weight branched and linear polyethylenimines for siRNA delivery.
Kubczak M, Michlewska S, Karimov M, Ewe A, Aigner A, Bryszewska M, Ionov M.
Nanotoxicology. 2022 Nov-Dec;16(9-10):867-882. doi: 10.1080/17435390.2022.2159891. Epub 2023 Jan 25.
PMID: 36697400
LPA receptor 1 (LPAR1) is a novel interaction partner of Filamin A that promotes Filamin A phosphorylation, MRTF-A transcriptional activity and oncogene-induced senescence.
Konopa A, Meier MA, Franz MJ, Bernardinelli E, Voegele AL, Atreya R, Ribback S, Roessler S, Aigner A, Singer K, Singer S, Sarikas A, Muehlich S.
Oncogenesis. 2022 Dec 28;11(1):69. doi: 10.1038/s41389-022-00445-z.
PMID: 36577757
Analysis of polymeric nanoparticle properties for siRNA/DNA delivery in a tumor xenograft tissue slice air-liquid interface model.
Karimov M, Scherer M, Franke H, Ewe A, Aigner A.
Biotechnol J. 2023 Apr;18(4):e2200415. doi: 10.1002/biot.202200415. Epub 2022 Dec 30.
PMID: 36541426
Experimental in vitro, ex vivo and in vivo models in prostate cancer research.
Sailer V, von Amsberg G, Duensing S, Kirfel J, Lieb V, Metzger E, Offermann A, Pantel K, Schuele R, Taubert H, Wach S, Perner S, Werner S, Aigner A.
Nat Rev Urol. 2023 Mar;20(3):158-178. doi: 10.1038/s41585-022-00677-z. Epub 2022 Nov 30.
PMID: 36451039
Therapeutic siRNA: State-of-the-Art and Future Perspectives.
Friedrich M, Aigner A.
BioDrugs. 2022 Sep;36(5):549-571. doi: 10.1007/s40259-022-00549-3. Epub 2022 Aug 23.
PMID: 35997897
Therapeutic miR-506-3p Replacement in Pancreatic Carcinoma Leads to Multiple Effects including Autophagy, Apoptosis, Senescence, and Mitochondrial Alterations In Vitro and In Vivo.
Borchardt H, Kogel A, Kalwa H, Weirauch U, Aigner A.
Biomedicines. 2022 Jul 13;10(7):1692. doi: 10.3390/biomedicines10071692.
PMID: 35884996
Characterization of Drug Release from Mesoporous SiO2-Based Membranes with Variable Pore Structure and Geometry.
Baumann F, Paul T, Wassersleben S, Regenthal R, Enke D, Aigner A.
Pharmaceutics. 2022 May 31;14(6):1184. doi: 10.3390/pharmaceutics14061184.
PMID: 35745757
Targeted Transposition of Minicircle DNA Using Single-Chain Antibody Conjugated Cyclodextrin-Modified Poly (Propylene Imine) Nanocarriers.
Jugel W, Tietze S, Daeg J, Appelhans D, Broghammer F, Aigner A, Karimov M, Schackert G, Temme A.
Cancers (Basel). 2022 Apr 11;14(8):1925. doi: 10.3390/cancers14081925.
PMID: 35454835
Impact of medication on blood transcriptome reveals off-target regulations of beta-blockers.
Rode M, Nenoff K, Wirkner K, Horn K, Teren A, Regenthal R, Loeffler M, Thiery J, Aigner A, Pott J, Kirsten H, Scholz M.
PLoS One. 2022 Apr 21;17(4):e0266897. doi: 10.1371/journal.pone.0266897. eCollection 2022.
PMID: 35446883
Amphiphilic Anionic Oligomer-Stabilized Calcium Phosphate Nanoparticles with Prospects in siRNA Delivery via Convection-Enhanced Delivery.
Mitrach F, Schmid M, Toussaint M, Dukic-Stefanovic S, Deuther-Conrad W, Franke H, Ewe A, Aigner A, Wölk C, Brust P, Hacker MC, Schulz-Siegmund M.
Pharmaceutics. 2022 Jan 29;14(2):326. doi: 10.3390/pharmaceutics14020326.
PMID: 35214058
Balancing Histone Deacetylase (HDAC) Inhibition and Drug-likeness: Biological and Physicochemical Evaluation of Class I Selective HDAC Inhibitors.
Schäker-Hübner L, Haschemi R, Büch T, Kraft FB, Brumme B, Schöler A, Jenke R, Meiler J, Aigner A, Bendas G, Hansen FK.
ChemMedChem. 2022 May 4;17(9):e202100755. doi: 10.1002/cmdc.202100755. Epub 2022 Feb 18.
PMID: 35073610
STAT3 Enhances Sensitivity of Glioblastoma to Drug-Induced Autophagy-Dependent Cell Death.
Remy J, Linder B, Weirauch U, Day BW, Stringer BW, Herold-Mende C, Aigner A, Krohn K, Kögel D.
Cancers (Basel). 2022 Jan 11;14(2):339. doi: 10.3390/cancers14020339.
PMID: 35053502
Unmodified and tyrosine-modified polyethylenimines as potential carriers for siRNA: Biophysical characterization and toxicity.
Kubczak M, Michlewska S, Karimov M, Ewe A, Noske S, Aigner A, Bryszewska M, Ionov M.
Int J Pharm. 2022 Feb 25;614:121468. doi: 10.1016/j.ijpharm.2022.121468. Epub 2022 Jan 11.
PMID: 35031413
Non-viral siRNA transfection of primary mesenchymal stromal cells (MSCs): Assessment of tyrosine-modified PEI and PPI efficacy and biocompatibility.
Noske S, Karimov M, Hansen M, Zatula N, Ewe A, Aigner A.
Int J Pharm. 2022 Jan 25;612:121359. doi: 10.1016/j.ijpharm.2021.121359. Epub 2021 Dec 8.
PMID: 34896217
A new player in the game: treatment with antagomiR-21a-5p significantly attenuates histological and echocardiographic effects of experimental autoimmune myocarditis.
Mirna M, Paar V, Topf A, Kraus T, Sotlar K, Aigner A, Ewe A, Watzinger S, Podesser BK, Hackl M, Pistulli R, Hoppe UC, Kiss A, Lichtenauer M.
Cardiovasc Res. 2022 Jan 29;118(2):556-572. doi: 10.1093/cvr/cvab015.
PMID: 33483746
HPA Axis Responsiveness Associates with Central Serotonin Transporter Availability in Human Obesity and Non-Obesity Controls.
Schinke C, Rullmann M, Luthardt J, Drabe M, Preller E, Becker GA, Patt M, Regenthal R, Zientek F, Sabri O, Then Bergh F, Hesse S.
Brain Sci. 2022 Oct 25;12(11):1430. doi: 10.3390/brainsci12111430.
PMID: 36358358
The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake.
Beinhölzl N, Molloy EN, Zsido RG, Richter T, Piecha FA, Zheleva G, Scharrer U, Regenthal R, Villringer A, Okon-Singer H, Sacher J.
Front Neurosci. 2022 Sep 9;16:809269. doi: 10.3389/fnins.2022.809269. eCollection 2022.
PMID: 36161146
Characterization of Drug Release from Mesoporous SiO2-Based Membranes with Variable Pore Structure and Geometry.
Baumann F, Paul T, Wassersleben S, Regenthal R, Enke D, Aigner A.
Pharmaceutics. 2022 May 31;14(6):1184. doi: 10.3390/pharmaceutics14061184.
PMID: 35745757
Noradrenergic deficits contribute to apathy in Parkinson's disease through the precision of expected outcomes.
Hezemans FH, Wolpe N, O'Callaghan C, Ye R, Rua C, Jones PS, Murley AG, Holland N, Regenthal R, Tsvetanov KA, Barker RA, Williams-Gray CH, Robbins TW, Passamonti L, Rowe JB.
PLoS Comput Biol. 2022 May 9;18(5):e1010079. doi: 10.1371/journal.pcbi.1010079. eCollection 2022 May.
PMID: 35533200
A Pharmacokinetic and Metabolism Study of the TRPC6 Inhibitor SH045 in Mice by LC-MS/MS.
Chai XN, Ludwig FA, Müglitz A, Gong Y, Schaefer M, Regenthal R, Krügel U.
Int J Mol Sci. 2022 Mar 26;23(7):3635. doi: 10.3390/ijms23073635.
PMID: 35408998
One-week escitalopram intake alters the excitation-inhibition balance in the healthy female brain.
Zsido RG, Molloy EN, Cesnaite E, Zheleva G, Beinhölzl N, Scharrer U, Piecha FA, Regenthal R, Villringer A, Nikulin VV, Sacher J.
Hum Brain Mapp. 2022 Apr 15;43(6):1868-1881. doi: 10.1002/hbm.25760. Epub 2022 Jan 22.
PMID: 35064716
Prefrontal Cortex Activation and Stopping Performance Underlie the Beneficial Effects of Atomoxetine on Response Inhibition in Healthy Volunteers and Those With Cocaine Use Disorder.
Zhukovsky P, Morein-Zamir S, Ziauddeen H, Fernandez-Egea E, Meng C, Regenthal R, Sahakian BJ, Bullmore ET, Robbins TW, Dalley JW, Ersche KD.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Nov;7(11):1116-1126. doi: 10.1016/j.bpsc.2021.08.010. Epub 2021 Sep 8.
PMID: 34508901
2021
Intracellular Amplifiers of Reactive Oxygen Species Affecting Mitochondria as Radiosensitizers.
Xu HG, Reshetnikov V, Wondrak M, Eckhardt L, Kunz-Schughart LA, Janko C, Tietze R, Alexiou C, Borchardt H, Aigner A, Gong W, Schmitt M, Sellner L, Daum S, Özkan HG, Mokhir A.
Cancers (Basel). 2021 Dec 31;14(1):208. doi: 10.3390/cancers14010208.
PMID: 35008371
Non-viral siRNA transfection of primary mesenchymal stromal cells (MSCs): Assessment of tyrosine-modified PEI and PPI efficacy and biocompatibility.
Noske S, Karimov M, Hansen M, Zatula N, Ewe A, Aigner A.
Int J Pharm. 2022 Jan 25;612:121359. doi: 10.1016/j.ijpharm.2021.121359. Epub 2021 Dec 8.
PMID: 34896217
Tetraspanin 5 (TSPAN5), a Novel Gatekeeper of the Tumor Suppressor DLC1 and Myocardin-Related Transcription Factors (MRTFs), Controls HCC Growth and Senescence.
Schreyer L, Mittermeier C, Franz MJ, Meier MA, Martin DE, Maier KC, Huebner K, Schneider-Stock R, Singer S, Holzer K, Fischer D, Ribback S, Liebl B, Gudermann T, Aigner A, Muehlich S.
Cancers (Basel). 2021 Oct 26;13(21):5373. doi: 10.3390/cancers13215373.
PMID: 34771537
Nanoparticles for local delivery of siRNA in lung therapy.
Kubczak M, Michlewska S, Bryszewska M, Aigner A, Ionov M.
Adv Drug Deliv Rev. 2021 Dec;179:114038. doi: 10.1016/j.addr.2021.114038. Epub 2021 Nov 3.
PMID: 34742826
Analysis of tripartite motif (TRIM) family gene expression in prostate cancer bone metastases.
Offermann A, Kang D, Watermann C, Weingart A, Hupe MC, Saraji A, Stegmann-Frehse J, Kruper R, Schüle R, Pantel K, Taubert H, Duensing S, Culig Z, Aigner A, Klapper W, Jonigk D, Philipp Kühnel M, Merseburger AS, Kirfel J, Sailer V, Perner S.
Carcinogenesis. 2021 Dec 31;42(12):1475-1484. doi: 10.1093/carcin/bgab083.
PMID: 34487169
Drug Delivery by Ultrasound-Responsive Nanocarriers for Cancer Treatment.
Entzian K, Aigner A.
Pharmaceutics. 2021 Jul 26;13(8):1135. doi: 10.3390/pharmaceutics13081135.
PMID: 34452096
Evaluation of Colon-Specific Plasma Nanovesicles as New Markers of Colorectal Cancer.
Nazarova I, Slyusarenko M, Sidina E, Nikiforova N, Semiglazov V, Semiglazova T, Aigner A, Rybakov E, Malek A.
Cancers (Basel). 2021 Aug 3;13(15):3905. doi: 10.3390/cancers13153905.
PMID: 34359806
Integrin alpha-V is an important driver in pancreatic adenocarcinoma progression.
Kemper M, Schiecke A, Maar H, Nikulin S, Poloznikov A, Galatenko V, Tachezy M, Gebauer F, Lange T, Riecken K, Tonevitsky A, Aigner A, Izbicki J, Schumacher U, Wicklein D.
J Exp Clin Cancer Res. 2021 Jun 26;40(1):214. doi: 10.1186/s13046-021-01946-2.
PMID: 34174926
Relevance of maternal sodium level for preeclampsia-associated adverse pregnancy outcomes.
Antonia Dröge L, Eidmann J, Aigner A, Frank L, Perschel FH, Henrich W, Verlohren S.
Pregnancy Hypertens. 2021 Aug;25:110-115. doi: 10.1016/j.preghy.2021.05.021. Epub 2021 May 29.
PMID: 34111835
Targeted RNAi of BIRC5/Survivin Using Antibody-Conjugated Poly(Propylene Imine)-Based Polyplexes Inhibits Growth of PSCA-Positive Tumors.
Jugel W, Aigner A, Michen S, Hagstotz A, Ewe A, Appelhans D, Schackert G, Temme A, Tietze S.
Pharmaceutics. 2021 May 8;13(5):676. doi: 10.3390/pharmaceutics13050676.
PMID: 34066833
Tyrosine-modified linear PEIs for highly efficacious and biocompatible siRNA delivery in vitro and in vivo.
Karimov M, Schulz M, Kahl T, Noske S, Kubczak M, Gockel I, Thieme R, Büch T, Reinert A, Ionov M, Bryszewska M, Franke H, Krügel U, Ewe A, Aigner A.
Nanomedicine. 2021 Aug;36:102403. doi: 10.1016/j.nano.2021.102403. Epub 2021 Apr 29.
PMID: 33932594
Nucleic acid delivery with extracellular vesicles.
Schulz-Siegmund M, Aigner A.
Adv Drug Deliv Rev. 2021 Jun;173:89-111. doi: 10.1016/j.addr.2021.03.005. Epub 2021 Mar 19.
PMID: 33746014
The combined disulfide cross-linking and tyrosine-modification of very low molecular weight linear PEI synergistically enhances transfection efficacies and improves biocompatibility.
Karimov M, Appelhans D, Ewe A, Aigner A.
Eur J Pharm Biopharm. 2021 Apr;161:56-65. doi: 10.1016/j.ejpb.2021.02.005. Epub 2021 Feb 11.
PMID: 33582186
Inhibition of HER Receptors Reveals Distinct Mechanisms of Compensatory Upregulation of Other HER Family Members: Basis for Acquired Resistance and for Combination Therapy.
Gutsch D, Jenke R, Büch T, Aigner A.
Cells. 2021 Jan 29;10(2):272. doi: 10.3390/cells10020272.
PMID: 33572976
Anticancer Therapy with HDAC Inhibitors: Mechanism-Based Combination Strategies and Future Perspectives.
Jenke R, Reßing N, Hansen FK, Aigner A, Büch T.
Cancers (Basel). 2021 Feb 5;13(4):634. doi: 10.3390/cancers13040634.
PMID: 33562653
miR24-3p activity after delivery into pancreatic carcinoma cell lines exerts profound tumor-inhibitory effects through distinct pathways of apoptosis and autophagy induction.
Borchardt H, Ewe A, Morawski M, Weirauch U, Aigner A.
Cancer Lett. 2021 Apr 10;503:174-184. doi: 10.1016/j.canlet.2021.01.018. Epub 2021 Jan 27.
PMID: 33508384
Methods to estimate proportion and number of nonexposed cases in a population.
Becher H, Aigner A.
Biom J. 2021 Mar;63(3):514-527. doi: 10.1002/bimj.201900190. Epub 2020 Nov 5.
PMID: 33150987
Prefrontal Cortex Activation and Stopping Performance Underlie the Beneficial Effects of Atomoxetine on Response Inhibition in Healthy Volunteers and Those With Cocaine Use Disorder.
Zhukovsky P, Morein-Zamir S, Ziauddeen H, Fernandez-Egea E, Meng C, Regenthal R, Sahakian BJ, Bullmore ET, Robbins TW, Dalley JW, Ersche KD.
Biol Psychiatry Cogn Neurosci Neuroimaging. 2022 Nov;7(11):1116-1126. doi: 10.1016/j.bpsc.2021.08.010. Epub 2021 Sep 8.
PMID: 34508901
The Rho kinase (ROCK) inhibitor Y-27632 reduces the β 2-adrenoceptor density but enhance cAMP formation in primary equine bronchial epithelial cells.
Schellenberg LM, Regenthal R, Abraham G.
Eur J Pharmacol. 2022 Jan 15;915:174724. doi: 10.1016/j.ejphar.2021.174724. Epub 2021 Dec 22.
PMID: 34953561
Presence and function of β-adrenergic receptors in primary equine bronchial epithelia cells.
Schellenberg LM, Bonicelli J, Hochheim I, Regenthal R, Abraham G.
Pulm Pharmacol Ther. 2021 Dec;71:102093. doi: 10.1016/j.pupt.2021.102093. Epub 2021 Nov 18.
PMID: 34801872
Expression of muscarinic acetylcholine receptors in turkey cardiac chambers.
Schoeller C, Hoffmann S, Adolph S, Regenthal R, Abraham G.
Res Vet Sci. 2021 Dec;141:145. doi: 10.1016/j.rvsc.2021.10.016. Epub 2021 Oct 29.
PMID: 34742102
Nutraceuticals in mental diseases – Bridging the gap between traditional use and modern pharmacology.
Regenthal R, Rong P, Krügel U.
Curr Opin Pharmacol. 2021 Dec;61:62-68. doi: 10.1016/j.coph.2021.08.017. Epub 2021 Oct 8.
PMID: 34628304
Locus coeruleus integrity and the effect of atomoxetine on response inhibition in Parkinson's disease.
O'Callaghan C, Hezemans FH, Ye R, Rua C, Jones PS, Murley AG, Holland N, Regenthal R, Tsvetanov KA, Wolpe N, Barker RA, Williams-Gray CH, Robbins TW, Passamonti L, Rowe JB.
Brain. 2021 Sep 4;144(8):2513-2526. doi: 10.1093/brain/awab142.
PMID: 33783470
Decreased thalamo-cortico connectivity during an implicit sequence motor learning task and 7 days escitalopram intake.
Molloy EN, Zsido RG, Piecha FA, Beinhölzl N, Scharrer U, Zheleva G, Regenthal R, Sehm B, Nikulin VV, Möller HE, Villringer A, Sacher J, Mueller K.
Sci Rep. 2021 Jul 23;11(1):15060. doi: 10.1038/s41598-021-94009-7.
PMID: 34301974
Modulation of premotor cortex response to sequence motor learning during escitalopram intake.
Molloy EN, Mueller K, Beinhölzl N, Blöchl M, Piecha FA, Pampel A, Steele CJ, Scharrer U, Zheleva G, Regenthal R, Sehm B, Nikulin VV, Möller HE, Villringer A, Sacher J.
J Cereb Blood Flow Metab. 2021 Jun;41(6):1449-1462. doi: 10.1177/0271678X20965161. Epub 2020 Nov 4.
PMID: 33148103
A single dose of escitalopram blunts the neural response in the thalamus and caudate during monetary loss.
Lewis CA, Mueller K, Zsido RG, Reinelt J, Regenthal R, Okon-Singer H, Forbes EE, Villringer A, Sacher J.
J Psychiatry Neurosci. 2021 Apr 27;46(3):E319-E327. doi: 10.1503/jpn.200121.
PMID: 33904667
Validation of an LC-MS/MS Method to Quantify the New TRPC6 Inhibitor SH045 (Larixyl N-methylcarbamate) and Its Application in an Exploratory Pharmacokinetic Study in Mice.
Chai XN, Ludwig FA, Müglitz A, Schaefer M, Yin HY, Brust P, Regenthal R, Krügel U.
Pharmaceuticals (Basel). 2021 Mar 13;14(3):259. doi: 10.3390/ph14030259.
PMID: 33805686
2020
Synthetic circular miR-21 RNA decoys enhance tumor suppressor expression and impair tumor growth in mice.
Müller S, Wedler A, Breuer J, Glaß M, Bley N, Lederer M, Haase J, Misiak C, Fuchs T, Ottmann A, Schmachtel T, Shalamova L, Ewe A, Aigner A, Rossbach O, Hüttelmaier S.
NAR Cancer. 2020 Jul 31;2(3):zcaa014. doi: 10.1093/narcan/zcaa014. eCollection 2020 Sep.
PMID: 34316687
SATB1-Mediated Upregulation of the Oncogenic Receptor Tyrosine Kinase HER3 Antagonizes MET Inhibition in Gastric Cancer Cells.
Jenke R, Holzhäuser-Rein M, Mueller-Wilke S, Lordick F, Aigner A, Büch T.
Int J Mol Sci. 2020 Dec 23;22(1):82. doi: 10.3390/ijms22010082.
PMID: 33374770
Nanoparticle-complexed antimiRs for inhibiting tumor growth and metastasis in prostate carcinoma and melanoma.
Kunz M, Brandl M, Bhattacharya A, Nobereit-Siegel L, Ewe A, Weirauch U, Hering D, Reinert A, Kalwa H, Guzman J, Weigelt K, Wach S, Taubert H, Aigner A.
J Nanobiotechnology. 2020 Nov 23;18(1):173. doi: 10.1186/s12951-020-00728-w.
PMID: 33228711
Methods to estimate proportion and number of nonexposed cases in a population.
Becher H, Aigner A.
Biom J. 2021 Mar;63(3):514-527. doi: 10.1002/bimj.201900190. Epub 2020 Nov 5.
PMID: 33150987
Glioblastoma Tissue Slice Tandem-Cultures for Quantitative Evaluation of Inhibitory Effects on Invasion and Growth.
Sidorcenco V, Krahnen L, Schulz M, Remy J, Kögel D, Temme A, Krügel U, Franke H, Aigner A.
Cancers (Basel). 2020 Sep 21;12(9):2707. doi: 10.3390/cancers12092707.
PMID: 32967361
Tyrosine-Modification of Polypropylenimine (PPI) and Polyethylenimine (PEI) Strongly Improves Efficacy of siRNA-Mediated Gene Knockdown.
Noske S, Karimov M, Aigner A, Ewe A.
Nanomaterials (Basel). 2020 Sep 10;10(9):1809. doi: 10.3390/nano10091809.
PMID: 32927826
Neurodevelopmental outcome at 2 years after neuroendoscopic lavage in neonates with posthemorrhagic hydrocephalus.
Behrens P, Tietze A, Walch E, Bittigau P, Bührer C, Schulz M, Aigner A, Thomale UW.
J Neurosurg Pediatr. 2020 Aug 7;26(5):495-503. doi: 10.3171/2020.5.PEDS20211. Print 2020 Nov 1.
PMID: 32764179
SATB1 as oncogenic driver and potential therapeutic target in head & neck squamous cell carcinoma (HNSCC).
Panchal O, Wichmann G, Grenman R, Eckhardt L, Kunz-Schughart LA, Franke H, Dietz A, Aigner A.
Sci Rep. 2020 May 25;10(1):8615. doi: 10.1038/s41598-020-65077-y.
PMID: 32451408
Determination of atomoxetine or escitalopram in human plasma by HPLC: Applications in neuroscience research studies.
Teichert J, Rowe JB, Ersche KD, Skandali N, Sacher J, Aigner A, Regenthal R.
Int J Clin Pharmacol Ther. 2020 Aug;58(8):426-438. doi: 10.5414/CP203705.
PMID: 32449675
The Role of lncRNAs TAPIR-1 and -2 as Diagnostic Markers and Potential Therapeutic Targets in Prostate Cancer.
Friedrich M, Wiedemann K, Reiche K, Puppel SH, Pfeifer G, Zipfel I, Binder S, Köhl U, Müller GA, Engeland K, Aigner A, Füssel S, Fröhner M, Peitzsch C, Dubrovska A, Rade M, Christ S, Schreiber S, Hackermüller J, Lehmann J, Toma MI, Muders MH, Sommer U, Baretton GB, Wirth M, Horn F.
Cancers (Basel). 2020 Apr 30;12(5):1122. doi: 10.3390/cancers12051122.
PMID: 32365858
Detection of doxorubicin, cisplatin and therapeutic antibodies in formalin-fixed paraffin-embedded human cancer cells.
Böckelmann L, Starzonek C, Niehoff AC, Karst U, Thomale J, Schlüter H, Bokemeyer C, Aigner A, Schumacher U.
Histochem Cell Biol. 2020 May;153(5):367-377. doi: 10.1007/s00418-020-01857-x. Epub 2020 Mar 3.
PMID: 32125512
Anti-CD3 Antibody Treatment Reduces Scar Formation in a Rat Model of Myocardial Infarction.
Wernly B, Paar V, Aigner A, Pilz PM, Podesser BK, Förster M, Jung C, Hofbauer JP, Tockner B, Wimmer M, Kraus T, Motloch LJ, Hackl M, Hoppe UC, Kiss A, Lichtenauer M.
Cells. 2020 Jan 25;9(2):295. doi: 10.3390/cells9020295.
PMID: 31991811
Inhibition of PIM2 in liver cancer decreases tumor cell proliferation in vitro and in vivo primarily through the modulation of cell cycle progression.
Kronschnabl P, Grünweller A, Hartmann RK, Aigner A, Weirauch U.
Int J Oncol. 2020 Feb;56(2):448-459. doi: 10.3892/ijo.2019.4936. Epub 2019 Dec 10.
PMID: 31894300
Extracellular vesicle (ECV)-modified polyethylenimine (PEI) complexes for enhanced siRNA delivery in vitro and in vivo.
Zhupanyn P, Ewe A, Büch T, Malek A, Rademacher P, Müller C, Reinert A, Jaimes Y, Aigner A.
J Control Release. 2020 Mar 10;319:63-76. doi: 10.1016/j.jconrel.2019.12.032. Epub 2019 Dec 19.
PMID: 31866504
Modulation of premotor cortex response to sequence motor learning during escitalopram intake.
Molloy EN, Mueller K, Beinhölzl N, Blöchl M, Piecha FA, Pampel A, Steele CJ, Scharrer U, Zheleva G, Regenthal R, Sehm B, Nikulin VV, Möller HE, Villringer A, Sacher J.
J Cereb Blood Flow Metab. 2021 Jun;41(6):1449-1462. doi: 10.1177/0271678X20965161. Epub 2020 Nov 4.
PMID: 33148103
Determination of atomoxetine or escitalopram in human plasma by HPLC: Applications in neuroscience research studies.
Teichert J, Rowe JB, Ersche KD, Skandali N, Sacher J, Aigner A, Regenthal R.
Int J Clin Pharmacol Ther. 2020 Aug;58(8):426-438. doi: 10.5414/CP203705.
PMID: 32449675
Presence and function of β-adrenergic receptors in primary equine bronchial epithelia cells.
Schellenberg LM, Bonicelli J, Hochheim I, Regenthal R, Abraham G.
Pulm Pharmacol Ther. 2020 Apr;61:101897. doi: 10.1016/j.pupt.2020.101897. Epub 2020 Jan 18.
PMID: 31962137
