Research profile

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DFG Collaborative Research Centre 1052

dfg-collaborative-research-centre-1052-medical-faculty.JPGThe aim of the joint research project 'Mechanisms of adiposity' is to investigate the aetiological mechanisms of morbid obesity, so that they can be used to inform new types of treatment. The project, which is being conducted with the participation of a large number of university institutions and research groups from the Helmholtz and Max Planck Institutes in Leipzig and Ben-Gurion University in Israel, adopts a highly interdisciplinary approach. Researchers are focusing on three key areas:

1. Overeating: An investigation into brain function and brain structure in adiposity, appetite modulation, satiety and reward systems, and the development of neurocognitive models of behaviour management

2. The function and distribution of adipose tissue: Identifying the genes which are partly responsible for the maldistribution and dysfunction of adipose tissue, and the identification and functional characterisation of key molecules involved in adipose tissue functioning

3. Adipose tissue hormones (adipokines): The effect of signals from the adipose tissue, the functioning of adipokines, and their role in the development of metabolic and cardiovascular diseases from childhood to adulthood