A path to better treatment of diseases of the peripheral and central nervous system
Acute and chronic damage to the nervous system are among the most common and often poorly treatable diseases.
In addition to neurodegenerative diseases such as Alzheimer's dementia, this also affects diseases of the glial cells, such as multiple sclerosis in the central nervous system or polyneuropathies in the peripheral nervous system. The interaction of glial cells with nerve cells and other cells of the nervous system is crucial for the development of these diseases, but has so far been poorly understood. We therefore aim to contribute to the development of new therapeutic strategies by gaining a better understanding of the degenerative and regenerative processes in the damaged nervous system.
Using transgenic techniques in mice, state-of-the-art behavioural and electrophysiological methods, ultra-high-resolution microscopy and molecular methods that allow us to examine individual cells and cell organelles, we aim to decipher pathological mechanisms and identify therapeutic targets that can be used to treat these serious neurological diseases.
