LeCMS develops novel analytical mass spectrometry-based concepts for metabolome and proteome analysis of human body fluids, tissues and cellular systems. These concepts are used to investigate metabolic and protein alterations as well as lipid modifications in dyslipidemia, metabolic syndrome and cardiovascular diseases. Targeted high-throughput approaches based on liquid chromatography tandem mass spectrometry (LC-MS/MS) and linear ion trap (LIT) technology as well as untargeted, discovery-based approaches implementing high resolution MS have been developed for application in large-scale cohort studies (e.g. LIFE-Heart and LIFE-Adult) for the investigation of systems-biological modulation of metabolic pathways. The mass spectrometry assays fulfill quality criteria in accordance with DIN EN ISO 15189:2014 and DIN EN ISO 17025:2005. The group has the expertise to translate in-house developed methods into routine clinical applications and to implement them.
