Sie sind hier: Skip Navigation LinksMental Health Dresden - Leipzig

Prof. Dr. med. Markus Loeffler

Research focus

  • Biometry of interventional clinical trials and cohort studies
  • Epidemiology of civilization diseases
  • Bioinformatics of multi-omics data, high-dimensional data analysis
  • Dynamic modeling of tissue organzization
  • Medical informatics on data accessibility of EMR

​​Official position

Full Professor and Director of the Institue of Medical Infrmatics, Statistics and Epidemiology Leipzig


Institute of Medical Informatics, Statistics and Epidemiology Leipzig 

Business address

Härtelstr. 16-18
04107 Leipzig


Academic education and degrees

1974 - 1980

Study of Medicine at Universtiy of Köln

1974 - 1982

Study of Physics at University of Köln


​Approbation to practise medicine


​Diploma in Physics


Dissertation (Dr. med.), University Köln


Habilitation and Venia Legendi in Medical Documentation, Statistics and Biomathematics, University Köln


​​Sabbatical Leave, Dept. Statistics, University Reading, England


Professional career

​1980 - 1984​​

Res​​earch assistant Biometry, University Köln

1984 - 1994

Research group leader Biometry, University Köln

Since 1994

Full Professor and Director of the Institute of Medical Informatics, Statistics and Epidemiology Leipzig (IMISE)

Since 1999

Scientific Director of the Center of Clinical Trials Leipzig (ZKS)

Since 2001

Scientific Director of the Interdisciplinary Center for Bioinformatics (IZBI)

Since 2009

Scientific Director of the LIFE Research Center for Civilization Diseases


Honors, awards and positions

Member of the Program Commission of the System Medicine Consortia (e:MED)

Member of the National Steering Committee of the Medical Informatics Initiative (MI-I)

Board of Directors of the German National Cohort (GNC)

Since 2018

PI of The SMITH Consortium of the Medical Informatics Initiative​


9 most important peer-reviewed papers (10 out of 394, Scopus h-index: 87)

  1. Winter A, Stäubert S, Ammon D, …, Löffler M. Smart Medical Information Technology for Healthcare (SMITH). Methods Inf Med. 2018;57(S 01):e92-e105.

  2. Loeffler M, Engel C, Ahnert P, Alfermann D, Arelin K, et al. The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany. BMC Public Health. 2015;15:691.

  3. Spada J, Scholz M, Kirsten H, …, Loeffler M, et al. Genome-wide association analysis of actigraphic sleep phenotypes in the LIFE Adult Study. J Sleep Res. 2016;25(6):690-701.

  4. Kharabian Masouleh S, Beyer F, Lampe L, Loeffler M, et al. Gray matter structural networks are associated with cardiovascular risk factors in healthy older adults. J Cereb Blood Flow Metab. 2018;38(2):360-372.

  5. Vojinovic D, Adams HH, Jian X, …, Loeffler M, et al. Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume. Nat Commun. 2018;9(1):3945.

  6. Satizabal CL, Adams HHH, Hibar DP, …, Loeffler M, et al. Genetic architecture of subcortical brain structures in 38,851 individuals. Nat Genet. 2019;51(11):1624-1636.

  7. Yahiaoui-Doktor M, Luck T, Riedel-Heller SG, Loeffler M, Wirkner K, Engel C. Olfactory function is associated with cognitive performance: results from the population-based LIFE-Adult-Study. Alzheimers Res Ther. 2019;11(1):43.

  8. Bloos F, Trips E, Nierhaus A, …, Loeffler M, Reinhart K; for SepNet Critical Care Trials Group. Effect of Sodium Selenite Administration and Procalcitonin-Guided Therapy on Mortality in Patients With Severe Sepsis or Septic Shock: A Randomized Clinical Trial. JAMA Intern Med. 2016;176(9):1266-76.

  9. Chapuy B, Stewart C, Dunford AJ, …, Loeffler M, et al. Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes. Nat Med. 2018;24(5):679-690​.

Semmelweisstraße 10, Haus 13
04103 Leipzig
0341 - 97 24539