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Prof. Dr. med. Thomas Arendt

Research focus

  • ​​​Alzheimer´s disease
  • Dementia
  • Neurodegeneration
  • Regulation of apoptosis and cell cycle 
  • Cytoskeleton, microtubule-associated protein tau 
  • Metabolism, Hypometabolism, Cryobiology and Hibernation
  • Extracellular Matrix
  • Biomarker​

​Official position

Managing Director

Institution

Paul Flechsig Institute of Brain Research​, Universität Leipzig, Medical Faculty

Business address

Liebigstr. 19
04103 Leipzig

Academic education and degrees

1990

Habilitation and venia legendi in Neuroscience, University of Leipzig, Germany

​1987

Medical Specialist (Biochemistry)

​1982

​Medical Thesis, University of Leipzig, Germany

​1982

​Graduation from Medical School, University of Leipzig

​1978

Medical Diploma, University of Leipzig, Germany​

 

Professional career

Since 1996

​Full Professor for Neuroanatomy, University of Leipzig

1987 - 1996

Research Group Leader, Paul Flechsig Inst. of Brain Research, Univ. Leipzig

1986 - 1987

Wellcome Fellow, Institute of Psychiatry, University of London

1984

​Visiting scientist, Academy of Medical Sciences, Moscow

1982 - 1986

PostDoc Paul Flechsig Institute of Brain Research, Dept. Neurochemistry

1982

Scientific Assistant, Institute for Medical Microbiology, Univ. Leipzig ​

​

Honors, awards and positions

2004

Alois Alzheimer Award of the Johann Wolfgang von Goethe University Frankfurt

2003

Nomination for the Luigi Amaducci Award

1995

Award of the German Brain League

1986

Welcome Trust Fellowship

1985

​Rudolf-Virchow-Award

1984

Award of the German Society for Experimental Medicine

1976

Lessing Award​

​

Current Journal Editorial positions 

Current

Managing Editorial board: Frontiers in Bioscience​

Current

​Editorial Board: Scientific Reports; Plos one; Neuroscience; American Journal of Neurodegenerative Disease; Journal of Neural Transmission; Journal of Neurodegeneration and Regeneration; Translational Neuroscience; Neurology Discovery

​

10 most important peer-reviewed papers (10 out of 376, Scopus h-index: 65)

  1. Nitsche A, Arnold C, Ueberham U, Reiche K, Fallmann J, Hackermüller J, Horn F, Stadler PF, Arendt T. Alzheimer-related genes show accelerated evolution. Mol Psychiatry. 2020 Mar 13. doi: 10.1038/s41380-020-0680-1. Online ahead of print. Mol Psychiatry. 2020. PMID: 3220315

  2. Doehner W, Praße L, Wolpers J, Brückner MK, Ueberham U, Arendt T. Transgenerational transmission of ​​an anticholinergic endophenotype with memory dysfunction. Neurobiol Aging. 2017;51:19-30

  3. Arendt T, Brückner MK, Lösche A. Regional mosaic genomic heterogeneity in the elderly and in Alzheimer's disease as a correlate of ne​uronal vulnerability. Acta Neuropathol. 2015;130(4​):501-10

  4. Fischer HG, Morawski M, Brückner MK, Mittag A, Tarnok A, Arendt T. Changes in neuronal DNA​​ content variation in the human brain during aging. Aging Cell. 2012;11(4):628-33

  5. Arendt T, Brückner MK, Mosch B, Lösche A. Selective cell death of hyperploid neurons in Alzhe​​imer's disease. Am J Pathol. 2010;177(1):15-20

  6. Enard W, Gehre S, Hammerschmidt K, Hölter SM, Blass T, Somel M, Brückner MK, Schreiweis C, Winter C, Sohr R, Becker L, Wiebe V, Nickel B, Giger T, Müller U, Groszer M, Adler T, Aguilar A, Bolle I, Calzada-Wack J, Dalke C, Ehrhardt N, Favor J, Fuchs H, Gailus-Durner V, Hans W, Hölzlwimmer G, Javaheri A, Kalaydjiev S, Kallnik M, Kling E, Kunder S, Mossbrugger I, Naton B, Racz I, Rathkolb B, Rozman J, Schrewe A, Busch DH, Graw J, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L, Schulz H, Wolf E, Wurst W, Zimmer A, Fisher SE, Morgenstern R, Arendt T, de Angelis MH, Fischer J, Schwarz J, Pääbo SA humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell. 2009;137(5):961-71

  7. Mosch B, Morawski M, Mittag A, Lenz D, Tarnok A, Arendt T Aneuploidy and DNA replication in the mormal human brain and Alzheimer´s disease. J Neurosci. 2007; 27:6859-6867

  8. Franz H, Ullmann C, Becker A, Ryan M, Bahn S, Arendt T, Simon M, Pääbo S, Khaitovich P. Systematic analysis of gene expression in human brains before and after death. Genome Biol. 2005;6:R112

  9. Arendt, Th., Stieler, J., Strijkstra, A. M., Hut, R. A., Rüdiger, J., Van der Zee, E. A., Harkany, T., Holzer, M., and Härtig, W. Reversible PHF-like phosphorylation of tau is an adaptive process associated with neuronal plasticity in hibernating animals. J Neurosci. 2003; 18:6972-6981

  10. Arendt, Th., Allen, Y., Sinden, J., Schugens, M. M., Marchbanks, R. M., Lantos, P. L., and Gray, J. A. Cholinergic-rich brain transplants reverse alcohol-induced memory deficits. Nature. 1988;332:448-450

Foto: Dr. Jens Stieler

Semmelweisstraße 10, Haus 13
04103 Leipzig
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