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PD Dr. Emanuel Severus, MD

Research focus

  • Bipolar Disorders
  • Digital Phenotyping
  • Ecological Momentary Assessment (EMA)
  • E-Mental Health
  • Research Domain Criteria (RDoC)

​Official position 

Consultant, Department of Psychiatry and Psychotherapy
Open-ended employment contract


Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus,Technische Universität Dresden, Dresden, Germany

Business address 

Fetscherstraße 74
01307 Dresden

Academic education and degrees

​1998 - 1996

MD in Medicine, School of Medicine, Humboldt-Universität zu Berlin

1997 - 1999,
2001-  2010

Residency in Psychiatry, Department of Psychiatry, FU Berlin & Department of Psychiatry, LMU München


Completion of PhD thesis


Postdoctoral lecture qualification (Habilitation) in Psychiatry, TU Dresden


Professional career

1991 - 2001

Research Fellow, Department of Psychiatry, McLean Hospital, Belmont, Harvard Medical School, Massachusetts, USA

​2007 - 2011

Senior Physician, Department of Psychiatry and Psychotherapy, LMU München

​2012 - 2013

Senior Physician, Department of Psychiatry and Psychotherapy, TU Dresden

​Since 2014

Consultant, Department of Psychiatry and Psychotherapy, TU Dresden


Honors, awards and positions


​Glaxo Wellcome Stipendium zur Erforschung Bipolarer Affektiver Störungen


Lilly Young Investigator Fellow in Bipolar Disorder

​2014 - 2019

​Focus Ärzteliste, “Top-Mediziner“ (Depression & Bipolare Störungen)


Current journal editorial positions

​Since 2012

Managing Editor, International Journal of Bipolar Disorders


10 most important peer-reviewed papers (10 out of 102, SCOPUS h-index: 24

  1. Severus WE, Grunze H, Kleindienst N, Frangou S, Moeller HJ. Is the prophylactic antidepressant efficacy of lithium in bipolar I disorder dependent on study design and lithium level? J Clin Psychopharmacol. 2005;25(5):457-62.

  2. Dittmann S, Seemüller F, Schwarz MJ, Kleindienst N, Stampfer R … Severus E. Association of cognitive deficits with elevated homocysteine levels in euthymic bipolar patients and its impact on psychosocial functioning: preliminary results. Bipolar Disord. 2007;9(1-2):63-70.

  3. Dittmann S, Seemüller F, Grunze HC, Schwarz MJ, Zach J … Severus WE. The impact of homocysteine levels on cognition in euthymic bipolar patients: a cross-sectional study. J Clin Psychiatry. 2008;69(6):899-906.

  4. Severus E, Lipkovich I, Seemüller F, Obermeier M, Grunze H et al. The potential role of Marginal Structural Models (MSMs) in testing the effectiveness of antidepressants in the treatment of patients with major depression in everyday clinical practice. World J Biol Psychiatry. 2013;14(5):386-95.

  5. Severus E, Seemüller F, Berger M, Dittmann S, Obermeier M et al. Mirroring everyday clinical practice in clinical trial design: a new concept to improve the external validity of randomized double-blind placebo-controlled trials in the pharmacological treatment of major depression. BMC Med. 2012;10:67.

  6. Voggt A, Berger M, Obermeier M, Löw A, Seemüller F … Severus E. Heart rate variability and omega-3 index in euthymic patients with bipolar disorders. Eur Psychiatry. 2015;30(2):228-32.

  7. Severus E, Sauer C, Bauer M, Ostacher M, Anghelescu IG. A novel study design to systematically explore the impact of trial methodology on psychopharmacological treatment outcome in patients with depression. Pharmacopsychiatry. 2019;52(4):170-174.

  8. Mühlbauer E, Bauer M, Ebner-Priemer U, Ritter P, Hill H … Severus E. Effectiveness of smartphone-based ambulatory assessment (SBAA-BD) including a predicting system for upcoming episodes in the long-term treatment of patients with bipolar disorders: study protocol for a randomized controlled single-blind trial. BMC Psychiatry. 2018 Oct 26;18(1):349.

  9. Nolen WA, Licht RW, Young AH, Malhi GS, Tohen M … Severus E. What is the optimal serum level for lithium in the maintenance treatment of bipolar disorder? A systematic review and recommendations from the ISBD/IGSLI Task Force on treatment with lithium. Bipolar Disord. 2019;21(5):394-409.

  10. Petzold J, Mayer-Pelinski R, Pilhatsch M, Luthe S … Severus E. Short group psychoeducation followed by daily electronic self-monitoring in the long-term treatment of bipolar disorders: a multicenter, rater-blind, randomized controlled trial. Int J Bipolar Disord. 2019 Nov 4;7(1):23.

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