Research
Neuregulin-1 belongs to the family of transmembrane and secreted growth factors and is crucial for the development of various mammalian organs such as the heart, lungs and nervous system. Neuregulin-1 is essential for controlling myelination of nerves. Diseases of the central nervous system such as schizophrenia or leukodystrophies are associated with impaired neuregulin-1 expression. In our research group we are investigating the neuregulin-1 signaling pathways in the central nervous system in order to understand the disease mechanisms and to find treatments for these so far incurable diseases.
Publications
ORCID-ID: 0000-0003-2477-2892
Götze T, Soto-Bernardini MC, Zhang M, Mießner H, Linhoff L, Brzózka MM, Velanac V, Dullin C, Ramos-Gomes F, Peng M, Husseini H, Schifferdecker E, Fledrich R, Sereda MW, Willig K, Alves F, Rossner MJ, Nave KA, Zhang W, Schwab MH. Hyperactivity is a Core Endophenotype of Elevated Neuregulin-1 Signaling in Embryonic Glutamatergic Networks. Schizophr Bull. 2021 Aug 21;47(5):1409-1420. doi: 10.1093/schbul/sbab027. PMID: 33871014.
Wehr MC, Hinrichs W, Brzózka MM, Unterbarnscheidt T, Herholt A, Wintgens JP, Papiol S, Soto-Bernardini MC, Kravchenko M, Zhang M, Nave KA, Wichert SP, Falkai P, Zhang W, Schwab MH, Rossner MJ. Spironolactone is an antagonist of NRG1-ERBB4 signaling and schizophrenia-relevant endophenotypes in mice. EMBO Mol Med. 2017 Oct;9(10):1448-1462. doi: 10.15252/emmm.201707691. PMID: 28743784.
Kronenberg J, Merkel L, Heckers S, Gudi V, Schwab MH, Stangel M. Investigation of Neuregulin-1 and Glial Cell-Derived Neurotrophic Factor in Rodent Astrocytes and Microglia. J Mol Neurosci. 2019 Mar;67(3):484-493. doi: 10.1007/s12031-019-1258-8. Epub 2019 Jan 25. Erratum in: J Mol Neurosci. 2019 Apr 5;: PMID: 30680593.
Agarwal A, Zhang M, Trembak-Duff I, Unterbarnscheidt T, Radyushkin K, Dibaj P, Martins de Souza D, Boretius S, Brzózka MM, Steffens H, Berning S, Teng Z, Gummert MN, Tantra M, Guest PC, Willig KI, Frahm J, Hell SW, Bahn S, Rossner MJ, Nave KA, Ehrenreich H, Zhang W, Schwab MH. Dysregulated expression of neuregulin-1 by cortical pyramidal neurons disrupts synaptic plasticity. Cell Rep. 2014 Aug 21;8(4):1130-45. doi: 10.1016/j.celrep.2014.07.026. Epub 2014 Aug 14. PMID: 25131210.
Team
- Hadiseh Hosseinnia (PhD Student)
- Maria Lehning (MD and PhD Student)
