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Research profile

DFG Collaborative Research Centre 1052

dfg-collaborative-research-centre-1052-medical-faculty.JPGThe aim of the joint research project 'Mechanisms of adiposity' is to investigate the aetiological mechanisms of morbid obesity, so that they can be used to inform new types of treatment. The project, which is being conducted with the participation of a large number of university institutions and research groups from the Helmholtz and Max Planck Institutes in Leipzig and Ben-Gurion University in Israel, adopts a highly interdisciplinary approach. Researchers are focusing on three key areas:

1. Overeating: An investigation into brain function and brain structure in adiposity, appetite modulation, satiety and reward systems, and the development of neurocognitive models of behaviour management

2. The function and distribution of adipose tissue: Identifying the genes which are partly responsible for the maldistribution and dysfunction of adipose tissue, and the identification and functional characterisation of key molecules involved in adipose tissue functioning

3. Adipose tissue hormones (adipokines): The effect of signals from the adipose tissue, the functioning of adipokines, and their role in the development of metabolic and cardiovascular diseases from childhood to adulthood

DFG Transregional Collaborative Research Centre TRR 67

dfg-transregional-collaborative-research-centre-trr67-medical-faculty.jpgMore than seventy scientists are engaged in the interdisciplinary joint research project 'Matrix engineering' in the search for new kinds of material to accelerate and improve wound healing following bone and skin injuries. The project is subdivided into two areas of research:

1. Matrix engineering: Materials scientists are developing new biochemical components, analysing them, and identifying their characteristics; these are then made available to the clinically oriented working groups.

2. Biologically active profiles in cell systems: During the next stage, the materials which have been developed are tested with various models, and then continuously improved to optimise their characteristics on the basis of feedback between the clinical researchers and the materials scientists.

The aim of the research project is to develop new kinds of functional biomaterials for improved regeneration of bone and skin.

DFG Research Unit FOR 2149

dfg-research-unit-medical-faculty.jpgCommunication between cells and the environment lies at the heart of the work of the research group on the ‘Elucidation of adhesion GPCR signalling. Cells communicate via receptor molecules, with G protein-coupled receptors (GPCRs) constituting a very large group of receptors. GPCRs play key roles in medicine; the majority of all prescription drugs act on these receptors. Little research has so far been conducted into the family of receptors known as adhesion G protein-coupled receptors (aGPCRs). Recent findings suggest that these receptor molecules play a crucial role in many biological functions, as well as in the development of disorders such as tumours. Scientists are engaged in eight sub-projects, where they are analysing the channels of communication between adhesion GPCRs.