Investigating the expression and function of CPEB proteins in neurons and astrocytes
23.06.2009, 16:00 - 17:30 Uhr - Vortrag
Cytoplasmic polyadenylation element binding proteins (CPEBs) are a family of translational regulators expressed in brain. They bind to mRNAs which contain the cytoplasmic polyadenylation element and control protein synthesis. Using transgenic mice expressing a dominant negative CPEB in forebrain neurons we found a role for CPEBs in synaptic plasticity, learning and memory as well as epilepsy. We tested whether CPEBs are relevant also in astroglia and found expression of all CPEBs in cultured astrocytes and acute hippocampal slices. Astrocytic overexpression of CPEB resulted in enlarged ventricles and overt behavioral abnormalities.
Strukturfunktionsbeziehungen und Interaktionen von Zellen: Aktuelle Konzepte und Pathophysiologie
- Dr. Martin Theis, Institute of Cellular Neurosciences, University of Bonn