Why care about magnesium? A TRiP to homeostasis
Why care about magnesium? A TR(i)P to homeostasis Vladimir Chubanov1, Annika Wisnowsky1, Silvia Ferioli1, Susanna Zierler1, Renate Heilmaier1, Ludmila Sytik1, David Simmons2, and Thomas Gudermann1 1Walther-Straub-Institut of Pharmacology and Toxicology, University of Munich, Germany 2School of Biomedical Sciences, The University of Queensland, Brisbane, Australia Magnesium is the most abundant divalent cation in living cells and virtually every biological process, e.g. enzyme and membrane function, maintenance of protein structure, ion channel regulation, requires this cation. Magnesium deficiency is associated with human diseases such as eclampsia, metabolic syndrome, type 2 diabetes and cardiovascular disease (hypertension, arrhythmia, atherosclerosis, myocardial infaction). However, the molecular mechanisms underlying organismal magensium homeostasis are only poorly understood. More than 15 magnesium permeable ion channels and transporters have been described whose biological significance, however, still remains largely obscure. Taking advantage of naturally occurring mutations in humans and several genetically engineered mouse models, we identify the Transient Receptor Potential (TRP) ion channel TRPM6 as the master regulator of organismal magnesium homeostasis essential for embryonic development and postnatal survival.
- Prof. Dr. Thomas Gudermann
- Prof. Dr. Achim Aigner