Archiv - April 2009

Vaspin serum concentrations in patients with carotid stenosis.

Gabriela Aust1 , Olaf Richter1, Silvio Rohm1, Christiane Kerner1, Johann Hauss1, Nora Klöting2, Karen Ruschke2, Peter Kovacs2, Byung-Soo Youn3 and Matthias Blüher2

1 Research Laboratories, Center of Surgery, Department of Visceral, Transplantation, Thoracic,
   and Vascular Surgery, University of Leipzig, Leipzig, Germany
2 Department of Medicine, University of Leipzig, Leipzig, Germany
3 AdipoGen, Inc., College of Life Science and Biotechnology, Korea University, Rm 641-B, 1,5-ka, Anam-dong, Sungbuk-ku, Seoul, South Korea

Atherosclerosis. 2008 Sep 2. [Epub ahead of print]

Abstract

Obesity is associated with accelerated atherosclerosis. Adipokines may directly influence vessel wall homeostasis by influencing the function of endothelial cells, arterial smooth muscle cells, and modulating inflammation. Recently, visceral adipose tissue-derived serpin (vaspin) was identified as a novel adipokine related to obesity and its metabolic consequences. However, the regulation of vaspin serum concentrations in human atherosclerosis is unknown. We therefore assessed vaspin serum concentrations in 107 consecutive patients with carotid stenosis undergoing carotid endarterectomy (CEA) in relation to severity of atherosclerosis, measures of obesity and circulating markers of obesity and atherosclerosis. Vaspin serum concentrations were significantly lower in patients with carotid stenosis who experienced an ischemic event within 3 months before surgery compared to asymptomatic patients. However, circulating vaspin was not associated with measures of atherosclerosis severity as maximum percentage stenosis. Vaspin serum concentrations were indistinguishable before and after CEA. We found a significant correlation between vaspin and leptin serum concentrations supporting previous results that vaspin closely reflects body fat mass. In conclusion, our data show that low vaspin serum concentrations correlate with recently experienced ischemic events in patients with carotid stenosis despite the lack of an association between circulating vaspin and parameters of atherosclerosis severity.

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