Artikel des Monats Juli 2006

Adipose tissue as source and target for novel therapies

Johannes Klein*, Nina Perwitz*, Daniel Kraus* and Mathias Fasshauer**

* Department of Internal Medicine I, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany
** Department of Internal Medicine III, University of Leipzig, Liebigstraße 27, 04103 Leipzig, Germany

Trends Endocrinol Metab. 2006 Jan-Feb;17(1):26-32. Epub 2005 Nov 23

Abstract

The physiology of adipose tissue has a key role in the pathogenesis of the metabolic syndrome and related cardiovascular disorders. Three main functions of adipocytes have been proposed to explain this role: the secretion of adipocyte-derived hormones (so-called adipokines), energy dissipation/thermogenesis, and energy storage. There is mounting evidence that this repertoire of actions and reactions contributes to whole-body glucose and energy homeostasis, the control of blood pressure, immune-system function, haemostasis and atherosclerosis. In this article we highlight the most recent examples of adipocyte-based therapies and discuss future pharmacological options for exploiting this triad of adipocyte functions.

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